PCB 3233 Exam 2 questions with 100% correct answers graded A+

PCB 3233 Exam 2

What are two cells that use receptors to distinguish between self and non-self cells? - correct answer
✔✔-Macrophages

-NK Cells



C3b is a ligand for - correct answer ✔✔Macrophage CR1



CR3 & CR4 - correct answer ✔✔Recognize iC3b & other ligands including LPS



Lectins - correct answer ✔✔Carbohydrates-binding proteins

ex: Mannose & glucose receptors



Scavenger Receptors - correct answer ✔✔Prefer molecules that are negatively charged like nucleic acids,
LPS.



Phagocytic Receptors - correct answer ✔✔Bind directly to microbial surface components



What do surface receptors promote? - correct answer ✔✔Phagocytosis



PRR's bind to - correct answer ✔✔PAMPs on pathogens



Receptors that detect microbial products signal what? - correct answer ✔✔-Macrophage activation

-Cytokine Secretion



Toll-Like Receptors (TLR) - correct answer ✔✔-10 receptors

-Has specificities for several microbial products

, TLR-4 - correct answer ✔✔-Senses LPS

-Found on macrophages



What can LPS cause? - correct answer ✔✔Septic Shock



What is LPS known for being? - correct answer ✔✔Endotoxin



What is local accumulation of fluid accompanied by? - correct answer ✔✔Swelling, redness, heat, & pain



What does increased dilation cause? - correct answer ✔✔Reduced blood flow



Complement receptors 3&4 (Mac-1, CD11b, CD8) target what? - correct answer ✔✔Bacteria & Fungi



CD14 binds to what? - correct answer ✔✔-LPS

-Peptidoglycan



What does IL-8 (CXCL-8) do? - correct answer ✔✔Attracts leukocytes (neutrophils) to the site of
infection/damage



What are your proinflammatory cytokines? - correct answer ✔✔-IL-1Beta

-IL-6

-CXCL8 (IL-8)

-IL-12

-TNF Alpha



What does TLR7 Recognize? - correct answer ✔✔-Ligand: Single stranded viral RNA

-Detects RNA viruses

-Carried by dendritic cells, NK cells, eosinophils, & B-cells