PACOP PCOL EXAM QUESTIONS AND CORRECT ANSWERS
Mechanism of action of local anesthetics - ANSWER Block sodium channels thereby
stopping axonal conduction
The ff are factors that affect the absorption of the drug from the GI tract EXCEPT:
a. SA of site of absorption
b. blood flow
c. physical state of drug
d. conc of drug at absorption site
e. protein binding - ANSWER E. protein binding
Continued stimulation of cells with agonists results to which of the ff:
a. desensitization
b. up-regulation
c. down-regulation
d. A and B
e. A and C - ANSWER E. A and C (desensitization and down-regulation)
Drug which has no intrinsic efficacy yet maintains affinity and therefore is in competition
with the agonist for the receptor binding site - ANSWER competitive antagonist
this class of drug exerts its effect through the binding of a site on the receptor different
from that of the main agonist and by altering the affinity of the receptor for the agonist -
ANSWER non-competitive antagonist
In this kind of study, the subjects are blinded to treatment assignment, but the
investigators are not. - ANSWER single blinded study
, The neurotransmitter of all preganglionic autonomic fibers and all postganglionic
parasympathetic fibers - ANSWER Acetylcholine
the release of acetylcholine and other neurotransmitters by exocytosis is inhibited by -
ANSWER botulinum toxin
all of the ff enzymes are involved in the biosynthesis of epinephrine from tyrosine
EXCEPT:
a. tyrosine hydroxylase
b. aromatic L-amino acid decarboxylase
c. dopamine Beta-hydroxylase
d. phenylethanolamine-N-methyl transferase
e. monoamine oxidase - ANSWER E. monoamine oxidase
Rate limiting enzyme in the synthesis of catecholamines - ANSWER Tyrosine
hydroxylase
All of the ff are effects of activating beta 2 receptor, EXCEPT:
A. Bronchoconstriction
B. Uterine relaxation
C. Glycogenolysis
D. Gluconeogenesis
E. Bronchodilation - ANSWER A. Bronchoconstriction
All of the ff are effects of activating alpha 1 receptor, EXCEPT:
A. vascular smooth muscle relaxation
B. Intestinal smooth muscle relaxation
C. Increase contractile force of the heart
Mechanism of action of local anesthetics - ANSWER Block sodium channels thereby
stopping axonal conduction
The ff are factors that affect the absorption of the drug from the GI tract EXCEPT:
a. SA of site of absorption
b. blood flow
c. physical state of drug
d. conc of drug at absorption site
e. protein binding - ANSWER E. protein binding
Continued stimulation of cells with agonists results to which of the ff:
a. desensitization
b. up-regulation
c. down-regulation
d. A and B
e. A and C - ANSWER E. A and C (desensitization and down-regulation)
Drug which has no intrinsic efficacy yet maintains affinity and therefore is in competition
with the agonist for the receptor binding site - ANSWER competitive antagonist
this class of drug exerts its effect through the binding of a site on the receptor different
from that of the main agonist and by altering the affinity of the receptor for the agonist -
ANSWER non-competitive antagonist
In this kind of study, the subjects are blinded to treatment assignment, but the
investigators are not. - ANSWER single blinded study
, The neurotransmitter of all preganglionic autonomic fibers and all postganglionic
parasympathetic fibers - ANSWER Acetylcholine
the release of acetylcholine and other neurotransmitters by exocytosis is inhibited by -
ANSWER botulinum toxin
all of the ff enzymes are involved in the biosynthesis of epinephrine from tyrosine
EXCEPT:
a. tyrosine hydroxylase
b. aromatic L-amino acid decarboxylase
c. dopamine Beta-hydroxylase
d. phenylethanolamine-N-methyl transferase
e. monoamine oxidase - ANSWER E. monoamine oxidase
Rate limiting enzyme in the synthesis of catecholamines - ANSWER Tyrosine
hydroxylase
All of the ff are effects of activating beta 2 receptor, EXCEPT:
A. Bronchoconstriction
B. Uterine relaxation
C. Glycogenolysis
D. Gluconeogenesis
E. Bronchodilation - ANSWER A. Bronchoconstriction
All of the ff are effects of activating alpha 1 receptor, EXCEPT:
A. vascular smooth muscle relaxation
B. Intestinal smooth muscle relaxation
C. Increase contractile force of the heart
