NURS 6024 PHARM EXAM 1|251 Questions with Verified
Answers
Having a DEA makes it so an APN can - CORRECT ANSWER prescribe
controlled/scheduled drugs
Schedule 1 drugs - CORRECT ANSWER Only research, high potential for abuse, not
medically useful
Schedule 2 drugs - CORRECT ANSWER High potential for abuse and have medical
use with severe restrictions
Schedule 3 drugs - CORRECT ANSWER Less potential for abuse and currently
accepted medical use
Schedule 4 drugs - CORRECT ANSWER drugs with a low potential for abuse and
low risk of dependence
Schedule 5 drugs - CORRECT ANSWER low abuse potential; no prescription
needed for adults over the age of 18
What are databases useful for when prescribing scheduled drugs - CORRECT
ANSWER Help know what other prescriptions have been prescribed to patient
ADME pertains to - CORRECT ANSWER pharmacokinetics
ADME stands for - CORRECT ANSWER Absorption
Distribution
Metabolism
Excretion
______ is the the drugs interactions within the body tissues. - CORRECT ANSWER
Pharmacodynamics
,Variability in drug response is due to _______. - CORRECT ANSWER
Pharmacogenetics
______ is the development and use of medications based on pharmacogenetics -
CORRECT ANSWER Pharmacogenomics
Absorption is from site of administration to _______ - CORRECT ANSWER the
blood stream
Distribution is - CORRECT ANSWER carrying to drugs site of action and reacting w/
receptor
Elimination happens through (2) - CORRECT ANSWER kidneys
feces
Water soluble cannot/can pass through cell membranes - CORRECT ANSWER
cannot
Lipid soluble cannot/can pass through cell membranes - CORRECT ANSWER can
Which is more likely to pass through the BBB, lipid or water soluble? - CORRECT
ANSWER Lipid
Weak acid drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER nonionized; more
Weak acid drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER ionized; less
Weak basic drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER Ionized; less
Weak basic drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER nonionized; more
Drugs are best absorbed in (ionized/nonionized) (water-soluble/lipid-soluble)
form. - CORRECT ANSWER nonionized; lipid soluble
, Cytochrome p450 enzymes are found primarily in the _____. They also can be
found in _____ (2) - CORRECT ANSWER liver
lungs; intestines
Grapejuice is an inhibitor making warfarin (increase/decrease) in the blood
stream. - CORRECT ANSWER Increase
Rifampin is an inducer of cytochrome p450. A pt taking warfarin and starts
rifampin will be at risk for (hemorrhage/clots). - CORRECT ANSWER Clots
Cockroft gault equation calculates - CORRECT ANSWER CrCl
How is a prodrug activated? - CORRECT ANSWER Metabolized in the liver
When a drug is metabolized, it is (inactivated/activated) except in the case of
______ where the opposite is true. - CORRECT ANSWER inactivated; prodrugs
Zero order elimination has a (curved/straight) graph - CORRECT ANSWER straight
First order elimination has a (curved/straight) graph - CORRECT ANSWER curved
A constant proportion of the drug is eliminated at a time in _________ - CORRECT
ANSWER First-order elimination
A constant amount per unit of time is metabolized in ________. - CORRECT
ANSWER Zero-order elimination
Which has a simple equation (multiply x2) to double a dose?
Zero-order elimination
First-order elimination - CORRECT ANSWER First-order elimination
Why might you not want to switch between certain drugs such as Lithium and
Phenytoin from brand to generic? - CORRECT ANSWER Narrow therapeutic
window. These drugs could be slightly different and still be approved.
Answers
Having a DEA makes it so an APN can - CORRECT ANSWER prescribe
controlled/scheduled drugs
Schedule 1 drugs - CORRECT ANSWER Only research, high potential for abuse, not
medically useful
Schedule 2 drugs - CORRECT ANSWER High potential for abuse and have medical
use with severe restrictions
Schedule 3 drugs - CORRECT ANSWER Less potential for abuse and currently
accepted medical use
Schedule 4 drugs - CORRECT ANSWER drugs with a low potential for abuse and
low risk of dependence
Schedule 5 drugs - CORRECT ANSWER low abuse potential; no prescription
needed for adults over the age of 18
What are databases useful for when prescribing scheduled drugs - CORRECT
ANSWER Help know what other prescriptions have been prescribed to patient
ADME pertains to - CORRECT ANSWER pharmacokinetics
ADME stands for - CORRECT ANSWER Absorption
Distribution
Metabolism
Excretion
______ is the the drugs interactions within the body tissues. - CORRECT ANSWER
Pharmacodynamics
,Variability in drug response is due to _______. - CORRECT ANSWER
Pharmacogenetics
______ is the development and use of medications based on pharmacogenetics -
CORRECT ANSWER Pharmacogenomics
Absorption is from site of administration to _______ - CORRECT ANSWER the
blood stream
Distribution is - CORRECT ANSWER carrying to drugs site of action and reacting w/
receptor
Elimination happens through (2) - CORRECT ANSWER kidneys
feces
Water soluble cannot/can pass through cell membranes - CORRECT ANSWER
cannot
Lipid soluble cannot/can pass through cell membranes - CORRECT ANSWER can
Which is more likely to pass through the BBB, lipid or water soluble? - CORRECT
ANSWER Lipid
Weak acid drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER nonionized; more
Weak acid drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER ionized; less
Weak basic drug in acid media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER Ionized; less
Weak basic drug in basic media is (ionized/nonionized) and (more/less) likely to
produce desired effect. - CORRECT ANSWER nonionized; more
Drugs are best absorbed in (ionized/nonionized) (water-soluble/lipid-soluble)
form. - CORRECT ANSWER nonionized; lipid soluble
, Cytochrome p450 enzymes are found primarily in the _____. They also can be
found in _____ (2) - CORRECT ANSWER liver
lungs; intestines
Grapejuice is an inhibitor making warfarin (increase/decrease) in the blood
stream. - CORRECT ANSWER Increase
Rifampin is an inducer of cytochrome p450. A pt taking warfarin and starts
rifampin will be at risk for (hemorrhage/clots). - CORRECT ANSWER Clots
Cockroft gault equation calculates - CORRECT ANSWER CrCl
How is a prodrug activated? - CORRECT ANSWER Metabolized in the liver
When a drug is metabolized, it is (inactivated/activated) except in the case of
______ where the opposite is true. - CORRECT ANSWER inactivated; prodrugs
Zero order elimination has a (curved/straight) graph - CORRECT ANSWER straight
First order elimination has a (curved/straight) graph - CORRECT ANSWER curved
A constant proportion of the drug is eliminated at a time in _________ - CORRECT
ANSWER First-order elimination
A constant amount per unit of time is metabolized in ________. - CORRECT
ANSWER Zero-order elimination
Which has a simple equation (multiply x2) to double a dose?
Zero-order elimination
First-order elimination - CORRECT ANSWER First-order elimination
Why might you not want to switch between certain drugs such as Lithium and
Phenytoin from brand to generic? - CORRECT ANSWER Narrow therapeutic
window. These drugs could be slightly different and still be approved.
