NSG 6005 Pharm Week 4 Respiratory, Asthma,
COPD, AntiHistamines Study
What are the four classes of asthma classification? - ANSWER ~
mild intermittent
mild persistant
moderate persistant
Severe persistant
What are the criteria for a person to be diagnosed with mild intermittent asthma?
- ANSWER ~ - Occur on fewer than 2 days a week.
- Nighttime symptoms occur on fewer than 2 days a month.
- Lung function tests (spirometry and peak expiratory flow[PEF]) are normal when
the person is not having an asthma attack.
- The results of these tests are 80% or more of the expected value and vary little
(PEF varies less than 20%) from morning to afternoon.
,what are the criteria to diagnose someone with mild persistent asthma? -
ANSWER ~ - Symptoms occur on more than 2 days a week but do
not occur every day.
- Nighttime symptoms occur > 2x a month
- Lung function tests are normal when the person is not having an asthma attack.
The results of these tests are 80% or more of the expected value and may vary a
small amount (PEF varies 20% to 30%) from morning to afternoon.
What are the criteria for diagnosing someone with moderate persistent asthma? -
ANSWER ~ - Symptoms occur daily
- Inhaled short-acting asthma medication is used every day.
- Symptoms interfere with daily activities.
Nighttime symptoms occur more than 1 time a week, but do not happen every
day.
- Lung function tests are abnormal (more than 60% to less than 80% of the
expected value), and PEF varies more than 30% from morning to afternoon.
What are the criteria for diagnosing someone with severe persistent asthma? -
ANSWER ~ - Occur throughout each day.
,- Severely limit daily physical activities.
- Nighttime symptoms occur often, sometimes every night.
- Lung function tests are abnormal (60% or less of expected value), and PEF varies
more than 30% from morning to afternoon.
What are the three components of asthma? - ANSWER ~ -
hypersensitivity
- inflammation (increased perm/mucous)
- smooth muscle contraction (obstruction)
How quickly and how long does a SABA work? - ANSWER ~
results within 5 minutes and last for 4-6 hours
***Significantly better bronchodilation than theophylline or anticholinergics
Should a LABA be used as mono therapy? - ANSWER ~ NO
Black box warning on all LABA- these drugs are not to be used alone-must be
combined with ICS due to risk of severe asthma exacerbations that are difficult to
tx and even asthma-related deaths
, When is a LABA used in therapy? - ANSWER ~ for chronic
therapy (lasts up to 12 hours) as an add on when asthma is not controlled with on
low to medium doses of corticosteroids
Can PO Beta2 agonists be used in acute severe asthma? - ANSWER ~
NO - delayed onset of action
**every patient is given a SABA for rescue
What is the difference between Albuterol and Levabuterol?
**both are SABA - ANSWER ~ Albuterol (mixture of R and S
isomers)
Levalbuterol (pure R) **suggested to cause less AE tachycardia
COPD, AntiHistamines Study
What are the four classes of asthma classification? - ANSWER ~
mild intermittent
mild persistant
moderate persistant
Severe persistant
What are the criteria for a person to be diagnosed with mild intermittent asthma?
- ANSWER ~ - Occur on fewer than 2 days a week.
- Nighttime symptoms occur on fewer than 2 days a month.
- Lung function tests (spirometry and peak expiratory flow[PEF]) are normal when
the person is not having an asthma attack.
- The results of these tests are 80% or more of the expected value and vary little
(PEF varies less than 20%) from morning to afternoon.
,what are the criteria to diagnose someone with mild persistent asthma? -
ANSWER ~ - Symptoms occur on more than 2 days a week but do
not occur every day.
- Nighttime symptoms occur > 2x a month
- Lung function tests are normal when the person is not having an asthma attack.
The results of these tests are 80% or more of the expected value and may vary a
small amount (PEF varies 20% to 30%) from morning to afternoon.
What are the criteria for diagnosing someone with moderate persistent asthma? -
ANSWER ~ - Symptoms occur daily
- Inhaled short-acting asthma medication is used every day.
- Symptoms interfere with daily activities.
Nighttime symptoms occur more than 1 time a week, but do not happen every
day.
- Lung function tests are abnormal (more than 60% to less than 80% of the
expected value), and PEF varies more than 30% from morning to afternoon.
What are the criteria for diagnosing someone with severe persistent asthma? -
ANSWER ~ - Occur throughout each day.
,- Severely limit daily physical activities.
- Nighttime symptoms occur often, sometimes every night.
- Lung function tests are abnormal (60% or less of expected value), and PEF varies
more than 30% from morning to afternoon.
What are the three components of asthma? - ANSWER ~ -
hypersensitivity
- inflammation (increased perm/mucous)
- smooth muscle contraction (obstruction)
How quickly and how long does a SABA work? - ANSWER ~
results within 5 minutes and last for 4-6 hours
***Significantly better bronchodilation than theophylline or anticholinergics
Should a LABA be used as mono therapy? - ANSWER ~ NO
Black box warning on all LABA- these drugs are not to be used alone-must be
combined with ICS due to risk of severe asthma exacerbations that are difficult to
tx and even asthma-related deaths
, When is a LABA used in therapy? - ANSWER ~ for chronic
therapy (lasts up to 12 hours) as an add on when asthma is not controlled with on
low to medium doses of corticosteroids
Can PO Beta2 agonists be used in acute severe asthma? - ANSWER ~
NO - delayed onset of action
**every patient is given a SABA for rescue
What is the difference between Albuterol and Levabuterol?
**both are SABA - ANSWER ~ Albuterol (mixture of R and S
isomers)
Levalbuterol (pure R) **suggested to cause less AE tachycardia
