AHN 554 HEM.ONC Exam 3 With
Complete Solution
Lab findings associate with IDA - ANSWER decreased hg
decreased to normal MCV
increased RDW or normal
increased ferritin
decreased transferring saturation
decreased iron
HYPOchromic, MICROcytic
Normal RBC levels - ANSWER Males 4.7-6.1 million/mm3
Females 4.2-5.4 million/mm3
Normal MCV levels - ANSWER 80-100fL
normal MCHC values - ANSWER 32-36%- normochromic
Normal RDW range - ANSWER 11.5-14.5%
Normal reticulocyte count - ANSWER 1-2%
What are reticulocytes? - ANSWER immature RBCs
Vitamin B12 normal range - ANSWER above 300 pg/mL
Normal folate level - ANSWER above 4 ng/mL
,What uncommon lab values are elevated in B12 deficiency? - ANSWER
homocysteine- elevated
methylmalonic acid(MMA)- elevated
What uncommon lab value is elevated in folate deficiency? - ANSWER
homocysteine- elevated
Normal ferritin levels - ANSWER 40-200 mcg/L
Ferritin level in severe IDA? - ANSWER less than 12
normal iron level - ANSWER 50-150 mcg/dL
Iron level in severe IDA? - ANSWER less than 40
TIBC normal range - ANSWER 250-450 mcg/dL
What is transferrin? - ANSWER iron transport protein
What is TIBC (Total Iron Binding Capacity) - ANSWER Measurement of
transferrin iron binding capability (1/3 of transferrin is typically bound with
iron)
normal transferrin levels - ANSWER Measured as a saturation ratio- Iron/TIBC
normal 20-50%
Transferrin level in IDA? - ANSWER less than 15%
What is sideroblastic anemia? - ANSWER -Hypochromic microocytic anemia
(can be normocytic or macrocytic)→ small size, lack of color
-Hereditary anemia characterized by inefficient iron uptake resulting in
dysfunctional hemoglobin synthesis
, -Not able to process iron, doesn't get stored/reused
- Can be caused from chemo/radiation
- reversible if caused by alcohol, medications, thiamine deficiency and copper
deficiency
What is aplastic anemia? - ANSWER - rare condition caused by failure of
blood cell production due to destruction of bone marrow cells
What can cause aplastic anemia? - ANSWER unknown but suspected from
benzene, HIV, EBV, sulfonamides, methimazole/PTU, SLE
Signs/symptoms of sideroblastic anemia? - ANSWER presents with iron
overload
symptoms of aplastic anemia - ANSWER Insidious onset of symptoms
Late symptoms include weakness, fatigue, lethargy, pallor, dyspnea,
palpitations, transient murmurs and tachycardia
Pancytopenia and granulocytopenia
What is pancytopenia? - ANSWER deficiency of all three cellular components
of the blood (red cells, white cells, and platelets).
Complete Solution
Lab findings associate with IDA - ANSWER decreased hg
decreased to normal MCV
increased RDW or normal
increased ferritin
decreased transferring saturation
decreased iron
HYPOchromic, MICROcytic
Normal RBC levels - ANSWER Males 4.7-6.1 million/mm3
Females 4.2-5.4 million/mm3
Normal MCV levels - ANSWER 80-100fL
normal MCHC values - ANSWER 32-36%- normochromic
Normal RDW range - ANSWER 11.5-14.5%
Normal reticulocyte count - ANSWER 1-2%
What are reticulocytes? - ANSWER immature RBCs
Vitamin B12 normal range - ANSWER above 300 pg/mL
Normal folate level - ANSWER above 4 ng/mL
,What uncommon lab values are elevated in B12 deficiency? - ANSWER
homocysteine- elevated
methylmalonic acid(MMA)- elevated
What uncommon lab value is elevated in folate deficiency? - ANSWER
homocysteine- elevated
Normal ferritin levels - ANSWER 40-200 mcg/L
Ferritin level in severe IDA? - ANSWER less than 12
normal iron level - ANSWER 50-150 mcg/dL
Iron level in severe IDA? - ANSWER less than 40
TIBC normal range - ANSWER 250-450 mcg/dL
What is transferrin? - ANSWER iron transport protein
What is TIBC (Total Iron Binding Capacity) - ANSWER Measurement of
transferrin iron binding capability (1/3 of transferrin is typically bound with
iron)
normal transferrin levels - ANSWER Measured as a saturation ratio- Iron/TIBC
normal 20-50%
Transferrin level in IDA? - ANSWER less than 15%
What is sideroblastic anemia? - ANSWER -Hypochromic microocytic anemia
(can be normocytic or macrocytic)→ small size, lack of color
-Hereditary anemia characterized by inefficient iron uptake resulting in
dysfunctional hemoglobin synthesis
, -Not able to process iron, doesn't get stored/reused
- Can be caused from chemo/radiation
- reversible if caused by alcohol, medications, thiamine deficiency and copper
deficiency
What is aplastic anemia? - ANSWER - rare condition caused by failure of
blood cell production due to destruction of bone marrow cells
What can cause aplastic anemia? - ANSWER unknown but suspected from
benzene, HIV, EBV, sulfonamides, methimazole/PTU, SLE
Signs/symptoms of sideroblastic anemia? - ANSWER presents with iron
overload
symptoms of aplastic anemia - ANSWER Insidious onset of symptoms
Late symptoms include weakness, fatigue, lethargy, pallor, dyspnea,
palpitations, transient murmurs and tachycardia
Pancytopenia and granulocytopenia
What is pancytopenia? - ANSWER deficiency of all three cellular components
of the blood (red cells, white cells, and platelets).
