Summary First year pharmacy at Newcastle university notes: Medicinal Chemistry

hinders nucleophile
a p p ro a c h

Speds up Sun as
it stabilises carbocation
-
Steric hinderance




&
Su1Manea SNeinverts least repulsion
pi orbitals can m a ke

racemic ste rcon
e
# Possible



wineo
must b e i n molecule nucleophilic electrons always m ove
towards electrophile




·
correct
geometry
↑
↑
neutralor-ve Donates




Numbe
Carbocation forms
in ↑ - e l e c t ro n

rate
determing step
.

(SN1) Identifyind nucleophiles


↑
Y h ave


nonbonding
↑ cone
pairs




SNc Nucleophiles Electrophiles
have ↓
empty
and
atomic

SM
als o anions

and Orbital
or With
antibanding
Ips .




↑ Orbita

Reactions Carbon Skeleton
↳ neutral or
-




↑
+ve
↳ - ↓
d SW does not
dependy secondary tertiary Identifying Electrophies
,
SN2 depends ↓
nucleophi le +
on on

electrophile
nucleophile
leaving group
good electrophiles have
a double or
single
d ↳ bond to atoms
mcronegative
Carbon S ke l e t o n
leaving group d
d
lower
memy secondary energy of
Orbital
primary

, M


N
" +
&
~
Y



Alv -
Al
O 11
-


Ome E
3
me Ome
ome

Et
o
⑦
N H

H
E
-
-




>
- 11
A - -
⑦ E
R
-
> REE
R R


Et -Xs -
E
N
S
NH2

-
NH2
He &
↳ Et H- Y
⑦
E
-




Ome
Ome
I M




-Doe
P >
-




Me
o
i Et
Ome




Ni
~
M
tin -
, 5
m Nu

Yu
S >
-

weo one



nome
o
me




-I or




Mo Nu



goo
O



y m
O o
↳
-




on


y
-




-

1 Nut
↓ w - -




us
↓

go
ou
va CI


V