©THEBRIGHTSTARS 2024
Introduction to PNM300 Exam Study Guide.
Pharmacotherapeutics, pharmacokinetics and pharmacodynamics - answer✔the study of the
therapeutic uses and effects of drugs
pharmacodynamics is the effect that drugs have on the body; while pharmacokinetics is the study
of the way in which drugs move through the body dur- ing absorption, distribution, metabolism
and excretion.
3 ways which drugs work: - answer✔receptor interaction, enzyme interaction, and non-
selective interaction (non-selective for a specific type of receptor)
four phases of pharmacokinetics (absorption, distribution, metabolism and excretion) -
answer✔across cell membrane into circulation.
Distribution: To target tissue
Lipid-soluble parent drug conversion to water-soluble for excretion
Site of drug metapolism - answer✔Liver
Distribution:
albumin binds...
Alpha 1 acid glycoprotein binds... - answer✔acidic drugs
basic drugs
Distribution:
For drugs to cross the blood brain barrier drug must be __ or ___ to diffuse accrose cells. -
answer✔lipid-soluble or,
non ionized form
Distribution:
Virtusally no barrier exist between drug and placenta. T or F - answer✔T
Metabolism/Biotransformation - answer✔breakdown or active metabolites
, ©THEBRIGHTSTARS 2024
Metabolite - answer✔the break down or the by-product of the parent drug which can be either
active or inactive.
First pass effect also called: - answer✔(presystemic metabolism)
Tolerance and dependence - answer✔Tolerance: i/c dosage
Dependence: Hooked
effects including additive, synergistic - answer✔synergistic (when the drug's effect is
increased) or antagonistic (when the drug's effect is decreased)
drug A + drug B = AB
use of Ontario Poison Centre and Motherisk services. - answer✔medicine, plants and industrial
chemicals. toxicology. treating poisonings and drug overdoses.
Treating the mother - Protecting the fetus/unborn
and identify the RPN scope of practice - answer✔performing a prescribed procedure below the
dermis or mucous membrane
■
administering a substance by injection or
inhalation
■
putting an instrument, hand or finger:
◗
beyond the external ear canal
◗
beyond the point in the nasal passages where
they normally narrow
◗
beyond the larynx
◗
Introduction to PNM300 Exam Study Guide.
Pharmacotherapeutics, pharmacokinetics and pharmacodynamics - answer✔the study of the
therapeutic uses and effects of drugs
pharmacodynamics is the effect that drugs have on the body; while pharmacokinetics is the study
of the way in which drugs move through the body dur- ing absorption, distribution, metabolism
and excretion.
3 ways which drugs work: - answer✔receptor interaction, enzyme interaction, and non-
selective interaction (non-selective for a specific type of receptor)
four phases of pharmacokinetics (absorption, distribution, metabolism and excretion) -
answer✔across cell membrane into circulation.
Distribution: To target tissue
Lipid-soluble parent drug conversion to water-soluble for excretion
Site of drug metapolism - answer✔Liver
Distribution:
albumin binds...
Alpha 1 acid glycoprotein binds... - answer✔acidic drugs
basic drugs
Distribution:
For drugs to cross the blood brain barrier drug must be __ or ___ to diffuse accrose cells. -
answer✔lipid-soluble or,
non ionized form
Distribution:
Virtusally no barrier exist between drug and placenta. T or F - answer✔T
Metabolism/Biotransformation - answer✔breakdown or active metabolites
, ©THEBRIGHTSTARS 2024
Metabolite - answer✔the break down or the by-product of the parent drug which can be either
active or inactive.
First pass effect also called: - answer✔(presystemic metabolism)
Tolerance and dependence - answer✔Tolerance: i/c dosage
Dependence: Hooked
effects including additive, synergistic - answer✔synergistic (when the drug's effect is
increased) or antagonistic (when the drug's effect is decreased)
drug A + drug B = AB
use of Ontario Poison Centre and Motherisk services. - answer✔medicine, plants and industrial
chemicals. toxicology. treating poisonings and drug overdoses.
Treating the mother - Protecting the fetus/unborn
and identify the RPN scope of practice - answer✔performing a prescribed procedure below the
dermis or mucous membrane
■
administering a substance by injection or
inhalation
■
putting an instrument, hand or finger:
◗
beyond the external ear canal
◗
beyond the point in the nasal passages where
they normally narrow
◗
beyond the larynx
◗
