ICM EXAM 2 LATEST 2024-2025 ACTUL QUESTIONS
AND CORRECT DETAILED ANSWERS GRADED A+
typical allergens that cause an allergic response
food, animals, pollen, dust, mold, insects, drugs
what serum immunoglobulin is utilized for allergy blood testing?
IgE
what type of hypersensitivity rxns are analphylactic (true allergy)?
type 1 hypersensitivity rxns
,Preferred allergy testing method when safety is an issue & why
allergy blood testing safer/ preferred over skin allergy testing in patients w/
anaphylactic rxn to unknown allergen
typical appearance of a positive allergy skin test
wheel (localized skin swelling) and/or erythema (redness of skin)
methods for allergy skin testing
-patch testing
-scratch testing (puncture)
-intradermal testing
least invasive allergy skin test
patch
describe patch testing
contact test - allegen placed on skin & area observed for rxn --delayed
hypersensitivity rxn (24-48 hrs after exposure)
skin allergy test w/ highest risk for anaphylaxis
,intradermal
disease type that ANCAs are used to assist in diagnosis of
autoimmune vasculitides (inflammatory conditions of blood vessels)
role of ANCAs
tests for autoantibodies in antigens in cytoplasm of neutrophils & monocytes
difference between pANCA & cANCA
pANCA- perinuclear area (area around the nucleus); antibody to MPO
(myeloperoxidase)
cANCA- cytoplasmic ANCA (in cytoplasm of cell); antibody to PR3 (Proteinase 3)
what other dx is pANCA useful for?
ulcer & colitis
describe antinuclear antibodies (ANA)
group of autoantibodies (autoantibodies attack normal cells) that attack the
nucleus (and other components) of cells
, use of ANA testing (what diseases)
non-specific autoimmune disease --tests for presence of an autoimmune disease,
not specific
-SLE
-SS
-Pylomyositis
-Scleroderma
-Raynaud's
-variety (others)
disease most associated w/ positive ANA
SLE (systemic lupus erythematosus)
implications of a +/- ANA test in the dx or exlcusion of SLE
ANA is highly specific for SLE (95%)
(-) test: can rule SLE out
(+) test: assocaited w/ SLE dx
AND CORRECT DETAILED ANSWERS GRADED A+
typical allergens that cause an allergic response
food, animals, pollen, dust, mold, insects, drugs
what serum immunoglobulin is utilized for allergy blood testing?
IgE
what type of hypersensitivity rxns are analphylactic (true allergy)?
type 1 hypersensitivity rxns
,Preferred allergy testing method when safety is an issue & why
allergy blood testing safer/ preferred over skin allergy testing in patients w/
anaphylactic rxn to unknown allergen
typical appearance of a positive allergy skin test
wheel (localized skin swelling) and/or erythema (redness of skin)
methods for allergy skin testing
-patch testing
-scratch testing (puncture)
-intradermal testing
least invasive allergy skin test
patch
describe patch testing
contact test - allegen placed on skin & area observed for rxn --delayed
hypersensitivity rxn (24-48 hrs after exposure)
skin allergy test w/ highest risk for anaphylaxis
,intradermal
disease type that ANCAs are used to assist in diagnosis of
autoimmune vasculitides (inflammatory conditions of blood vessels)
role of ANCAs
tests for autoantibodies in antigens in cytoplasm of neutrophils & monocytes
difference between pANCA & cANCA
pANCA- perinuclear area (area around the nucleus); antibody to MPO
(myeloperoxidase)
cANCA- cytoplasmic ANCA (in cytoplasm of cell); antibody to PR3 (Proteinase 3)
what other dx is pANCA useful for?
ulcer & colitis
describe antinuclear antibodies (ANA)
group of autoantibodies (autoantibodies attack normal cells) that attack the
nucleus (and other components) of cells
, use of ANA testing (what diseases)
non-specific autoimmune disease --tests for presence of an autoimmune disease,
not specific
-SLE
-SS
-Pylomyositis
-Scleroderma
-Raynaud's
-variety (others)
disease most associated w/ positive ANA
SLE (systemic lupus erythematosus)
implications of a +/- ANA test in the dx or exlcusion of SLE
ANA is highly specific for SLE (95%)
(-) test: can rule SLE out
(+) test: assocaited w/ SLE dx
