NR 546 / NR546 Actual Final Exam 2024 Prediction questions (All correct
answers, Already graded A)
PrefrontalrCortexrSymptomsrofrMDDr-rcorrectranswer-rConcentration
MentalrFatigue
Mood
PFCr&rAmygdalarSymptomsrofrMDDr-rcorrectranswer-rGuilt
Suicidality
Worthlessness
StriatumrSymptomsrofrMDDr-rcorrectranswer-rPhysicalrfatigue
NucleusrAccumbensrSymptomsrofrMDDr-rcorrectranswer-rPleasurerinterests
HypothalamusrSymptomsrofrMDDr-rcorrectranswer-rSleep
Appetite
Thalamusr&rHypothalamusrSymptomsrofrManiar-rcorrectranswer-rDecreasedrsleep/arousal
StriatumrSymptomsrofrManiar-rcorrectranswer-rMotor/agitation
Prefrontalrcortexr(PFC)rSymptomsrofrManiar-rcorrectranswer-rRisk-taking
Talkative/pressuredrspeech
NucleusrAccumbensr&rPFCrSymptomsrofrManiar-rcorrectranswer-rRacingrthoughts,rgrandiosity
PFCr&rAmygdalarSymptomsrofrManiar-rcorrectranswer-rMood
,MedicationrManagementr-rcorrectranswer-rSSRI-SelectiverSerotoninrReuptakerInhibitors
*Inhibitr5rHTrreuptake
SNRI-SerotoninrNorepinephrinerReuptakerInhibitorsr
*inhibitr5-HTrreuptake
*inhibitrNErreuptaker(increaserenergy,rfocus)
*increaserDArinrprefrontalrcortexr(increasercognition)
NDRI-NorepinephrinerDopaminerReuptakerinhibitors
*inhibitrDArreuptaker(increaseralertness,rmotivation)
*inhibitrNErreuptaker(increaserenergy)
SARI-SerotoninrAntagonistrReuptakerInhibitors
SelectiverSerotoninrReuptakerInhibitorsr(SSRIs):rMostradversereffectsrwillrsubsiderafterr4-
5rdaysroncertherbodyradjustsrtorincreasedrserotoninrlevels.r-rcorrectranswer-rdiarrhea
headache
weightrgain
sexualrsidereffects
SerotoninrNorepinephrinerReuptakerInhibitorsr(SNRIs):rMedicationsrshouldrnotrberabruptlyrstoppedrtoravoi
drdiscontinuationrsymptoms.rNEreffectsrofrthermedicationrmayrincreaseranxietyrinrsomerclients.rReportrwor
seningranxietyrtortherprovider.r-rcorrectranswer-relevatedrbloodrpressure
anxiety
insomnia
constipation
NorepinephrinerDopaminerReuptakerInhibitorsr(NDRI):rTakermedicationrinrthermorning.rStoprtakingrmedica
tionrifrseizuresroccur.rStoprtakingrmedicationrifranxietyrisrnoted.r-rcorrectranswer-ragitation
headache
dryrmouth
constipation
weightrloss
,escitalopramr(Lexapro)rSSRIr-rcorrectranswer-rnorknownrdrugrinteractions
bestrtoleratedrSSRI
27-32rhourrhalf-lifergoodrforrforgetfulrpronerclients
leastrCYPrreactions
Substraterforr3A4
citalopramr(Celexa)rSSRIr-rcorrectranswer-rmildrantihistaminereffects;rHalf-Life:r23-45rhours
WeakrInhibitorrofr2D6
fluoxetiner(Prozac)rSSRIr-rcorrectranswer-rlongestrhalf-life
Usercautionrinrpatientsrwithrcomorbidranxietyrduertorriskrforractivationrandrpanicrattacks
Half-Life:r2-3rdaysrparent,r2rweekrmetabolite
Inhibitsr2D6randr3A4
paroxetiner(Paxil)rSSRIr-rcorrectranswer-ralsortreatsrsocialranxietyrandrinsomnia
associatedrwithrweightrgain
willrexperiencerwithdrawalrwithrmissedrdoserorrabruptrstop
Half-Life:r24rhours
Inhibitsr2D6
fluvoxaminer(Luvox)rSSRIr-rcorrectranswer-rtreatsranxiousrdepressionrsmokersrrequireranrincreasedrdose
Half-Life:r9-28rhours
Inhibitsr3A4,r2C9,r1A2
sertraliner(Zoloft)rSSRIr-rcorrectranswer-ralsortreatsrsocialranxietyrandrhypersomnolence
Half-Life:r22-36rhourrparent;r62-104rhourrmetabolite
Inhibitsr2D6randr3A4rweaklyratrlowrdoses
, venlafaxiner(Effexor)r-rcorrectranswer-
rtreatsrbothrdepressionrandranxietyrdisorders,rensurertrialrofrhigherrdoserbeforerswitchingrtorardifferentrme
dication
Half-life:rParentrdrugr3-7rhour;rmetaboliterhasr9-13rhour
duloxetiner(Cymbalta)rSNRIr-rcorrectranswer-
reffectiverforratypicalrpainratrhigherrdoses;rappropriaterforrclientsrwhorpresentrwithrsomaticrsymptomsrofrd
epression;reffectiverforratypicalrpain,rsuchrasrfibromyalgiarandrdiabeticrneuropathy
Half-Life:r12rhours
Inhibitorrofr2D6
bupropionr(Wellbutrin)r-rcorrectranswer-rNDRIrmayrimproverenergy,ralertness,randrmotivation;rnotrfirst-
linertreatmentrforranxiety;rcontraindicatedrinrclientsrwithrarhistoryrofrseizures
Avoidrinrpatientsrwithrcomorbidranxiety
Half-Life:rParentr10-14rhours;rMetaboliter20-27rhours
Inhibitsr2D6
SerotoninrAntagonistrandrReuptakerInhibitorsr(SARIs)r-rcorrectranswer-rSARIsrpotentlyrblockr5-
HT2Arandr5HTr2Crreceptors,rwhichrallowrmorer5-HTrtorinteractratrpostsynapticr5-
HT1Arsites.rSerotoninrblockaderandrreuptakerinhibitionrisrpresentratrhigherrdoses.
Trazodoner-rcorrectranswer-rThermostrcommonrSARI,ralsorblocksrhistaminergicrandrα-adrenergicrreceptors.
Half-Life:r3-6rhours
SerotoninrAntagonistrandrReuptakerInhibitorsr(SARIs)r-rcorrectranswer-rCommonrAdverserEffects
·rsedation
·rdrowsiness
·rblurredrvision
·rconstipation
·rdryrmouth
SeriousrAdverserEffect
answers, Already graded A)
PrefrontalrCortexrSymptomsrofrMDDr-rcorrectranswer-rConcentration
MentalrFatigue
Mood
PFCr&rAmygdalarSymptomsrofrMDDr-rcorrectranswer-rGuilt
Suicidality
Worthlessness
StriatumrSymptomsrofrMDDr-rcorrectranswer-rPhysicalrfatigue
NucleusrAccumbensrSymptomsrofrMDDr-rcorrectranswer-rPleasurerinterests
HypothalamusrSymptomsrofrMDDr-rcorrectranswer-rSleep
Appetite
Thalamusr&rHypothalamusrSymptomsrofrManiar-rcorrectranswer-rDecreasedrsleep/arousal
StriatumrSymptomsrofrManiar-rcorrectranswer-rMotor/agitation
Prefrontalrcortexr(PFC)rSymptomsrofrManiar-rcorrectranswer-rRisk-taking
Talkative/pressuredrspeech
NucleusrAccumbensr&rPFCrSymptomsrofrManiar-rcorrectranswer-rRacingrthoughts,rgrandiosity
PFCr&rAmygdalarSymptomsrofrManiar-rcorrectranswer-rMood
,MedicationrManagementr-rcorrectranswer-rSSRI-SelectiverSerotoninrReuptakerInhibitors
*Inhibitr5rHTrreuptake
SNRI-SerotoninrNorepinephrinerReuptakerInhibitorsr
*inhibitr5-HTrreuptake
*inhibitrNErreuptaker(increaserenergy,rfocus)
*increaserDArinrprefrontalrcortexr(increasercognition)
NDRI-NorepinephrinerDopaminerReuptakerinhibitors
*inhibitrDArreuptaker(increaseralertness,rmotivation)
*inhibitrNErreuptaker(increaserenergy)
SARI-SerotoninrAntagonistrReuptakerInhibitors
SelectiverSerotoninrReuptakerInhibitorsr(SSRIs):rMostradversereffectsrwillrsubsiderafterr4-
5rdaysroncertherbodyradjustsrtorincreasedrserotoninrlevels.r-rcorrectranswer-rdiarrhea
headache
weightrgain
sexualrsidereffects
SerotoninrNorepinephrinerReuptakerInhibitorsr(SNRIs):rMedicationsrshouldrnotrberabruptlyrstoppedrtoravoi
drdiscontinuationrsymptoms.rNEreffectsrofrthermedicationrmayrincreaseranxietyrinrsomerclients.rReportrwor
seningranxietyrtortherprovider.r-rcorrectranswer-relevatedrbloodrpressure
anxiety
insomnia
constipation
NorepinephrinerDopaminerReuptakerInhibitorsr(NDRI):rTakermedicationrinrthermorning.rStoprtakingrmedica
tionrifrseizuresroccur.rStoprtakingrmedicationrifranxietyrisrnoted.r-rcorrectranswer-ragitation
headache
dryrmouth
constipation
weightrloss
,escitalopramr(Lexapro)rSSRIr-rcorrectranswer-rnorknownrdrugrinteractions
bestrtoleratedrSSRI
27-32rhourrhalf-lifergoodrforrforgetfulrpronerclients
leastrCYPrreactions
Substraterforr3A4
citalopramr(Celexa)rSSRIr-rcorrectranswer-rmildrantihistaminereffects;rHalf-Life:r23-45rhours
WeakrInhibitorrofr2D6
fluoxetiner(Prozac)rSSRIr-rcorrectranswer-rlongestrhalf-life
Usercautionrinrpatientsrwithrcomorbidranxietyrduertorriskrforractivationrandrpanicrattacks
Half-Life:r2-3rdaysrparent,r2rweekrmetabolite
Inhibitsr2D6randr3A4
paroxetiner(Paxil)rSSRIr-rcorrectranswer-ralsortreatsrsocialranxietyrandrinsomnia
associatedrwithrweightrgain
willrexperiencerwithdrawalrwithrmissedrdoserorrabruptrstop
Half-Life:r24rhours
Inhibitsr2D6
fluvoxaminer(Luvox)rSSRIr-rcorrectranswer-rtreatsranxiousrdepressionrsmokersrrequireranrincreasedrdose
Half-Life:r9-28rhours
Inhibitsr3A4,r2C9,r1A2
sertraliner(Zoloft)rSSRIr-rcorrectranswer-ralsortreatsrsocialranxietyrandrhypersomnolence
Half-Life:r22-36rhourrparent;r62-104rhourrmetabolite
Inhibitsr2D6randr3A4rweaklyratrlowrdoses
, venlafaxiner(Effexor)r-rcorrectranswer-
rtreatsrbothrdepressionrandranxietyrdisorders,rensurertrialrofrhigherrdoserbeforerswitchingrtorardifferentrme
dication
Half-life:rParentrdrugr3-7rhour;rmetaboliterhasr9-13rhour
duloxetiner(Cymbalta)rSNRIr-rcorrectranswer-
reffectiverforratypicalrpainratrhigherrdoses;rappropriaterforrclientsrwhorpresentrwithrsomaticrsymptomsrofrd
epression;reffectiverforratypicalrpain,rsuchrasrfibromyalgiarandrdiabeticrneuropathy
Half-Life:r12rhours
Inhibitorrofr2D6
bupropionr(Wellbutrin)r-rcorrectranswer-rNDRIrmayrimproverenergy,ralertness,randrmotivation;rnotrfirst-
linertreatmentrforranxiety;rcontraindicatedrinrclientsrwithrarhistoryrofrseizures
Avoidrinrpatientsrwithrcomorbidranxiety
Half-Life:rParentr10-14rhours;rMetaboliter20-27rhours
Inhibitsr2D6
SerotoninrAntagonistrandrReuptakerInhibitorsr(SARIs)r-rcorrectranswer-rSARIsrpotentlyrblockr5-
HT2Arandr5HTr2Crreceptors,rwhichrallowrmorer5-HTrtorinteractratrpostsynapticr5-
HT1Arsites.rSerotoninrblockaderandrreuptakerinhibitionrisrpresentratrhigherrdoses.
Trazodoner-rcorrectranswer-rThermostrcommonrSARI,ralsorblocksrhistaminergicrandrα-adrenergicrreceptors.
Half-Life:r3-6rhours
SerotoninrAntagonistrandrReuptakerInhibitorsr(SARIs)r-rcorrectranswer-rCommonrAdverserEffects
·rsedation
·rdrowsiness
·rblurredrvision
·rconstipation
·rdryrmouth
SeriousrAdverserEffect
