PMY302 wk1; Questions with Complete Solutions
True or False
There is no absorption phase when delivering a drug IV because absorption is the process of
entering the bloodstream from another body compartment such as the stomach or intestine
CORRECT ANS-True
Highly lipid soluble molecules more easily cross biological membranes. What would happen if
a lipid soluble drug was given a charge (e.g. proton)?
A. Would not change the properties of the drug
B. Would more easily pass biological membranes
C. Would less easily pass biological membranes CORRECT ANS-C. Would less easily pass
biological membranes
True or False
Certain individuals with liver damage would have a decrease in "first pass" metabolism,
therefore, careful metering of their dose is advised as bioavailability may be increased
CORRECT ANS-True
True or False
, PMY302 wk1; Questions with Complete Solutions
If a drug has high absorption and high serum binding, it would be more appropriate for
targeting receptors in the vasculature than targeting receptors in the brain. CORRECT ANS-
True
True or False
A highly lipid soluble drug, which can easily pass biological membranes and has low serum
binding, would have a low distribution of volume. CORRECT ANS-False
True or False
Charged molecules are inherently hydrophilic and not lipophilic, therefore they do not pass
biological membranes well. CORRECT ANS-True
Attributes of an individual that may impact the biotransformation and elimination of a drug
include:
Diet
mutations within liver enzymes
mutations within solute carriers
liver disease
, PMY302 wk1; Questions with Complete Solutions
kidney disease
age CORRECT ANS-all of the above
True or False
Not only does high serum affinity interfere with the ability of a drug to distribute to tissues, it
also decreases excretion. CORRECT ANS-True
Which are true statements of zero-order kinetics?
A. the amount of drug eliminated per hour is constant
B. the time at which half the drug is eliminated is constant
C. is often seen with high drug concentrations
D. there is liver disease CORRECT ANS-A, C, D
True or False
You have been prescribed to take one 50mg tablet of a drug every 12 hours. It would be the
same, from a drug plasma concentration perspective, to take two 50mg tablet every 24 hours.
CORRECT ANS-False
True or False
There is no absorption phase when delivering a drug IV because absorption is the process of
entering the bloodstream from another body compartment such as the stomach or intestine
CORRECT ANS-True
Highly lipid soluble molecules more easily cross biological membranes. What would happen if
a lipid soluble drug was given a charge (e.g. proton)?
A. Would not change the properties of the drug
B. Would more easily pass biological membranes
C. Would less easily pass biological membranes CORRECT ANS-C. Would less easily pass
biological membranes
True or False
Certain individuals with liver damage would have a decrease in "first pass" metabolism,
therefore, careful metering of their dose is advised as bioavailability may be increased
CORRECT ANS-True
True or False
, PMY302 wk1; Questions with Complete Solutions
If a drug has high absorption and high serum binding, it would be more appropriate for
targeting receptors in the vasculature than targeting receptors in the brain. CORRECT ANS-
True
True or False
A highly lipid soluble drug, which can easily pass biological membranes and has low serum
binding, would have a low distribution of volume. CORRECT ANS-False
True or False
Charged molecules are inherently hydrophilic and not lipophilic, therefore they do not pass
biological membranes well. CORRECT ANS-True
Attributes of an individual that may impact the biotransformation and elimination of a drug
include:
Diet
mutations within liver enzymes
mutations within solute carriers
liver disease
, PMY302 wk1; Questions with Complete Solutions
kidney disease
age CORRECT ANS-all of the above
True or False
Not only does high serum affinity interfere with the ability of a drug to distribute to tissues, it
also decreases excretion. CORRECT ANS-True
Which are true statements of zero-order kinetics?
A. the amount of drug eliminated per hour is constant
B. the time at which half the drug is eliminated is constant
C. is often seen with high drug concentrations
D. there is liver disease CORRECT ANS-A, C, D
True or False
You have been prescribed to take one 50mg tablet of a drug every 12 hours. It would be the
same, from a drug plasma concentration perspective, to take two 50mg tablet every 24 hours.
CORRECT ANS-False
