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NURS 657 PHARMACOLOGY WEEK 1 AND 2 STUDY GUIDE – DOWNLOAD TO ATTAIN AN A+

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NURS 657 PHARMACOLOGY WEEK 1 AND 2 STUDY GUIDE – DOWNLOAD TO ATTAIN AN A+ • A patient diagnosed with chronic pain calls to request an oxycodone (Oxycontin) refill. Which action should the prescriber take initially? o Arrange to schedule an appt w/the pt • A metered-dose albuterol inhaler is prescribed for asthma management. The patient reports feeling jittery sometimes when taking the medication, and does not feel that the medication is always effective. Which action will the provider take to best minimize patient risks and maximize medication effectiveness? o Auscultate the pt’s lung sounds & obtain other relevant vital signs • A patient reports that a medication prescribed for recurrent migraine headaches is not working. Which action is the prescriber’s priority when addressing the patient's concern? o Ask the pt about the number & frequency of tablets taken • The drug manual states that older adult patients are at increased risk for hepatotoxicity. Which action is most important when prescribing this medication to an 80-year-old patient? o Obtaining baseline liver function studies • A patient with bipolar disorder is prescribed daily lithium. Which action is most important for the provider to take in order to determine if the therapeutic level is maintained? o Order periodic lab testing • Which factor best supports an increase for full prescriptive authority for both advanced practice registered nurses (APRNs) and physician assistants (PAs)? o More pts will have access to health care • Which prescriber action will have the greatest impact on the patient’s commitment to adherence to any type of medication therapy? o Providing med education that the pt can easily understand • Which patient statement suggests to the provider that the patient’s nonadherence with their medication plan is related to dissatisfaction with the therapy? o “I’ve been taking this med for well over a week & I lost only a half a pound” • How can the prescriber’s regular collaboration with a pharmacist improve positive outcomes for patients? (Select all that apply.) o Pharmacists have additional info on drug interaction o Pharmacists can suggest adequate med dosing o Pharmacists have firsthand knowledge of the facility formulary • Which statements made by the prescriber demonstrate an understanding of effective medication education? (Select all that apply.) o “This med needs to be stored in the fridge” o “Take 3 tabs daily: 1 w/breakfast, 1 w/lunch, & 1 w/dinner” o “You need to take the med as we discussed until all the tabs are gone” o “Call the office immediately if you begin experiencing any itching, HA, or difficulty breathing” • The patient who has been prescribed lithium for a diagnosis of bipolar disorder asks why blood tests are required on a regular basis. Which provider responses demonstrate an understanding of why the patient requires a variety of laboratory tests? (Select all that apply.) o “We need to monitor how your thyroid is functioning” o “We need to monitor kidney function while you’re on this drug” o “This med can cause you to lose Na, so we need to measure Na levels” • When prescribing drugs with a narrow therapeutic index, what intervention does the provider take to decrease risk to the patient? o Monitor the pt’s plasma drug levels at regular intervals • A patient reports that a medication no longer effectively alleviates symptoms. What process informs the provider’s response to the patient’s concerns? o Desensitization of receptor sites results from continual exposure to the drug • A patient reports that Brand X tablets work faster than Brand Y tablets of the same amount of the same drug. Which statement informs the prescriber’s response when explaining this phenomenon to the patient? o Inactive ingredients used in the composition can result in differing rates of dissolution, which can alter the drug’s onset of action • A patient receiving intravenous gentamicin has a toxic serum drug level. The prescriber confirms that the dosing is correct. Which possible cause of this situation will the provider explore? o Whether pt is taking a med that binds to serum albumin • A patient takes a drug that is metabolized by CYP3A4 isoenzymes. If a CYP3A4 inducing drug is prescribed, what drug adjustment may be necessary to maintain a therapeutic level of CYP3A4 substrate? o Increase dosage of the CYP3A4 • What instructions should the provider give regarding alcohol intake while taking hydrocodone with acetaminophen for postsurgical pain? • “You should avoid drinking alcohol while you are taking the pain med I’ve ordered” • Which order for furosemide is written appropriately by the prescriber? • Furosemide [Lasix] 20mg PO daily • What action should the prescriber take to minimize the potential risk of a drug-induced Parkinson-like syndrome? • Thoroughly educate the pt about recognizing such symp & the need to notify the office immediately • What instructions should the provider give when a patient reports mild nausea after taking a newly approved medication that does not list nausea as a known side effect? • “Take the next dose w/food & call the office if the nausea reoccurs or if other symp develop” • What medication-induced effect would lead the prescriber to discontinue a newly prescribed medication in a patient who develops shortness of breath shortly after taking the initial dose? • A side effect • What response should the provider give when asked by a patient about the purpose of genetic testing before prescribing a medication? • “Testing will tell us how quickly your body is likely to metabolize or process the drug” • What does the provider suspect is responsible for a patient taking more than the prescribed dosage of a narcotic analgesic for chronic pain for several months? • The pt has developed pharmacodynamic tolerance, which has increased the minimum effective concentration (MEC) needed for analgesic effect • Which patient ethnic ancestry creates a risk factor that may result in minimal beneficial response to tamoxifen therapy? • French • Before initiating cetuximab therapy, what condition should the provider order epidermal growth factor receptor (EGFR) testing for the patient? • Colorectal cancer • What information should the prescriber include when prescribing a new medication with regard to pharmacogenomics and its benefits? • Provide definitions & possible examples of related idiosyncratic responses to this med • What aspects of a female patient’s medical history should the provider be particularly concerned about when prescribing a medication that induces P-glycoprotein (PGP)? • Intestinal probs • Kidney function • Liver function • What is important for the provider to consider when prescribing medications to infants? • Breastfeeding infants are more likely to develop toxicity when the mother is taking lipid-soluble drugs • Immaturity of renal function in infancy causes infants to excrete drugs less efficiently • Infants have immature livers, which slows drug metabolism • Infants are more sensitive to meds that act on the central nervous system (CNS) • What should the provider consider when prescribing two drugs that compete for plasma albumin receptor sites? o Binding of one or both agents will be reduced o Plasma levels of free drug will rise • What actions occur in most fatal medication errors? o Giving a drug IV instead of IM o Giving an incorrect med that sounds the same o Writing a prescription illegible • What serious conditions will a patient with a genetic deficiency in the biomarker CYP2C19 be at risk for if prescribed clopidogrel? • Myocardial infarction • During which time period is the risk of teratogen-induced gross malformations highest? • 1st trimester • What should the provider tell a pregnant patient about the safe use of medications during the third trimester? • “They may need to be given in higher doses if they undergo renal clearance” • What instructions should the prescriber give a breastfeeding patient who must take a prescription medication for 2 weeks to minimize the amount of the drug her baby receives? • “Take the med immediately after breastfeeding your baby” • Which type of medication prescribed to a pregnant patient is more likely to have effects on her fetus? • Lipid-soluble drugs • Why is more not known about the teratogenic effects of maternal medication ingestion during pregnancy, and how should the provider address the patient’s concern? • “Clinical trials to determine teratogenic effects would put the fetus at risk” • What information should the provider use to address the parents’ question about using a topical antihistamine for an infant with a pruritic rash? • Applying an antihistamine to the skin can cause toxicity in this age group • Why can't children with asthma use the same inhalers as adults, and how should the provider address the parents' concern? • A child attending daycare is prescribed 750 mg of an antibiotic for 10 days. The drug may be dosed in several ways and is available in two concentrations. Which dosing regimen will the provider consider to best assure drug adherence? • 375mg of a 500mg/5mL solution PO twice daily • A 5-year-old has gray teeth. When taking a medication history, the provider will ask about previous use of which group of medications? • Tetracyclines • A provider is concerned about renal function in an 84-year-old patient who is taking several medications. What laboratory result will the provider order? • Creatinine clearance • An older adult patient with a history of forgetfulness will need to take multiple drugs after discharge from the hospital. What provider action will most successfully promote medication adherence in a forgetful patient? • Schedule meds to be taken at the same time as much as possible • A provider is reviewing an older adult patient’s chart during a routine visit. Which patient information is of most concern regarding the renewing of medication prescriptions for highly protein- bound drugs? • Low serum albumin • Four older adult patients are taking multiple medications. For which patient is the provider most concerned about the risk for adverse drug effects? • An underweight pt w/a chronically low appetite • An older adult patient is entering into the immediate postoperative period after a total hip replacement. The patient’s son concerned about related pain asks meperidine be prescribed since, “I had it for severe pain when I injured when I was younger.” What action will the provider take to reduce the patient’s risk for injury while addressing the patient’s pain? • Prescribe morphine & discuss the rationale w/the pt’s son • An older adult patient is admitted to the hospital for treatment of an exacerbation of a chronic illness. Admission laboratory work reveals an extremely low serum drug level of the drug used to treat this condition. The patient’s renal and hepatic function tests are normal. What might the provider suspect as a likely cause of this finding? • Nonadherence to the medical regimen • A provider obtains a drug history from an older adult who is a new patient. Of the multiple medications taken, which two, taken together, create a reason for concern? • Amitriptyline & diphenhydramine • A frail older adult patient is admitted to the hospital after several days of vomiting, diarrhea, poor intake of foods and fluids, and anuria for 8 hours. What laboratory studies will the provider order to help guide medication administration? (Select all that apply.) • Creatinine clearance • Plasma drug levels • Serum albumin • A patient diagnosed with Parkinson disease (PD) begins treatment with levodopa/carbidopa. After several months of therapy, the patient reports no change in symptoms. The provider will implement what action? • Re-evaluate the diagnosis (levodopa/carbidopa is so effective that a dx of PD should be questioned if the pt fails to respond in this time frame) • A patient who takes levodopa/carbidopa for Parkinson disease reports periods of lost drug effect lasting from minutes to several hours with no relationship to the timing of drug administration. What course of action will the provider take? • Administering a catechol-O-methyltransferase (COMT) inhibitor, such as entacapone (pt describing “off” phenomenon) • When selecting a dopamine agonist for a patient with Parkinson disease, the provider identifies which side effect associated with pramipexole as being less likely to occur than with other dopamine agonists? • Sleep attacks • A patient has been newly diagnosed with Parkinson disease. Before beginning therapy with pramipexole, the provider will ask the patient which assessment question in order to minimize risk for injury? o Any hx of alcohol abuse or compulsive behaviors (pramipexole has been associated w/impulse control disorders) • A hospitalized patient newly diagnosed with Parkinson disease is prescribed apomorphine but develops medication-related nausea and vomiting. What drug will the provider prescribe to manage these side effects effectively? o Trimethobenzamide (can be used as antiemetic) • The provider prescribes bromocriptine for a patient who takes levodopa/carbidopa. Afterward, the patient becomes agitated and has frequent nightmares. What action will the provider take to manage the patient’s symptoms? o Reducing the dose to minimize side effects • An infant is prescribed a central nervous system (CNS) drug. The parents are concerned that the child exhibits unusual drowsiness and sedation. The provider explains these effects based on an understanding of which difference in the physiology of infants and adults? o Blood-brain barrier What is tachyphylaxis Tolerance resulting from repeated dosing over a short time Genetic testing for variants in CYP2C9 is recommended for which drug Warfarin The provider prepares a pt w/newly diagnosed DM1 for hospital d/c. Which action by the provider will best support the pt’s ability to effectively manage med therapy Asking the pt to demonstrate how to measure & admin insulin A pt is prescribed metronidazole for bacterial vaginosis. Which p thx finding would be most concerning to the provider The pt drinks 2 glasses of wine every night A pediatric pt prescribed ampicillin for streptococcal pharyngitis reports new onset of a pruritic, dull red, maculopapular rash on the chest & neck. Which action is most important to take to minimize this pt’s risk for injury D/C the ampicillin An APRN works in a urology clinic under the supervision of a physician who does not restrict the type of meds the APRN is allowed to prescribe. State law does not require the APRN to practice under physician supervision. How would the APRN’s prescriptive authority be described Independent Which factors could be attributed to limited prescriptive authority for APRNs - Inaccessibility of pt care - Higher health care costs Which aspects support the APRNs provision for full prescriptive authority - Clinical education includes prescription of meds & disease processes - National examinations provide validation of the APRNs ability to provide safe care - Licensure ensures compliance w/health care & safety standards A FNP practicing in Maine is hired at a practice across state lines in Virginia. Which aspect of practice may change for the APRN The APRN will have less prescriptive authority in the new position What level is monitored for pts taking warfarin PT/INR Meds w/narrow therapeutic index - Carbamazepine - Digoxin - Lithium - Phenytoin - Theophylline When prescribing lovastatin, what will a provider advise to decrease the risk of developing muscle toxicity Sub grapefruit juice for OJ A pt who has been taking sertraline for D/C the azithromycin & write an order for an depression was prescribed azithromycin to treat an infection by a provider at an after-hrs clinic. What action will the PCP take to address the risk this combo of med has posed for the pt alternative antibiotic A pt is prescribed digoxin. Which screening will the provider order to monitor for potential adverse effects from this drug Serum electrolytes A provider considers prescribing tamoxifen for a woman w/breast cancer. Upon reviewing results of genetic testing, the prescriber notes that the pt has variations in the CYP2D6 allele resulting in a deficiency of the CYP2D6 isoenzymes. What action will this deficiency warrant in the prescribing of tamoxifen, a CYP2D6 substrate Tamoxifen will not be prescribed The parents of a child w/asthma ask the provider why their child can’t use oral corticosteroids more often, bc they are so effective. The provider will base the discussion w/the parents on what fact concerning oral corticosteroids Chronic glucocorticoid use can inhibit physical growth An infant is prescribed a med that has a narrow therapeutic range & is excreted by the kidneys. The provider will monitor closely for which effect Evidence of drug toxicity A med prescribed for a neonate is eliminated primarily by hepatic metabolism. What action will the prescriber take to minimize risk to the infant Prescribe a dose that is relatively lower than an adult dose when adjusted for body surface area A pediatric provider is teaching nursing students to calculate med doses for children using a formula based on body surface area. Which statement by a nursing student indicates understanding of the teaching “This formula helps approximate the 1st dose, other doses should be based on clinical observations” A pt has been taking oxycodone to manage severe, chronic pain for the last 6mo. But now reports that it’s no longer effective. The provider will discuss prescribing which med for the pt Fentanyl transdermal patch A pt has been taking methadone for 5mo to overcome an opioid addiction. The provider will monitor the pt for which electrocardiographic change Prolonged QT interval A pt receives an epidural anesthetic during labor & deliver. What effect in the newborn in Bradycardia the immediate postpartum period must the provider be prepared to address A provider has prescribed the topical anesthetic lidocaine for a pt who has a 2nd degree burn on one arm. Which statement by the pt indicates understanding of the teaching regarding this treatment “I will apply a thin layer of the med to only the burned area” Within a few min of administration a local anesthetic, the pt has a pulse of 54 bpm, resp of 18 breaths/min, & BP of 90/42mm Hg. The provider should monitor the pt for further signs of what condition Heart block The provider used lidocaine w/epinephrine as a local anesthetic when suturing a laceration on a pt’s hand. Following the procedure, which pt symp causes the most concern Nervousness & tachycardia The provider has prescribed a vasoconstrictor to be given in combo w/a local anesthetic. What is the expected goal for this action A reduction of the risk of anesthetic toxicity, a prolonging of the anesthetic effect A pt w/advanced renal carcinoma is prescribed aldesleukin as part of the tx regimen. What adverse effect of this drug will be a concern for the provider Capillary leakage syndrome A provider orders tamoxifen for a premenopausal woman w/ ER-positive breast cancer. What supports the provider’s decision to prescribe tamoxifen over anastrozole Anastrozole will not be effective until she is postmenopausal A provider considers cancer prophylaxis w/tamoxifen for a 45y/o pt w/a family hx of breast cancer. According to her health hx, she had 1 child at age 35 & developed DVT during the pregnancy. She has not had a hysterectomy. What info from the pt’s hx informs the provider’s decision regarding tamoxifen Her hx of DVT outweighs any possible benefit she may have with this drug (Tamoxifen contraindicated if DVT) Which statement correctly informs a provider’s decision regarding whether to order an antiestrogen drug or an aromatase inhibitor for tx of breast cancer Antiestrogen drugs increase the risk for endometrial cancer A provider teaches a pt about a vesicant chemotherapeutic agent. Which statement by the pt indicates a need for further teaching about this type of drug “These drugs may be administered orally as well as intravenously” A pt asks why a combo product containing an opioid analgesic & a nonsteroidal anti- inflammatory drug (NSAID) has been “The combo provides increased pain relief than when either product is used alone” prescribed to manage cancer pain. Which response will the provider give the pt A pt w/cancer uses a fentanyl transdermal patch for pain relief. The pt reports having 3 or 4 episodes of severe pain lasting 30min most days. What action will the provider take to address the pt’s pain Prescribe a strong, short-acting opioid PRN Oxycodone is ordered eery 4-6hrs PRN for a pt newly diagnosed w/cancer who is admitted to the hospital. The pt requests pain med whenever reporting pain as a 7 or 8 on a scale of 1-10, but then tells the nurse the med is not working well. What action will the provider take when learning of this situation Prescribe a fixed dosing schedule for the oxycodone A pt who takes hydrocodone & ibuprofen for cancer pain is admitted to the hospital for chemotherapy. What action will the prescriber take regarding the prescribed ibuprofen D/C the ibuprofen A pt w/cancer has taken oxycodone & a NSAID for a year. At a follow-up visit, the pt reports an increase in pain intensity w/a new “burning & shooting” pain. What prescription will the provider write to address the pt’s current pain Fentanyl transdermal patch, acetaminophen, & an adjunctive analgesic A pt newly dx w/cancer reports having pain at a level of 7-8 on a scale of 10. Which type of pain management will be prescribed initially by the provider to manage this pt’s pain Opioid analgesics A pt w/cancer who has been taking an opioid analgesic reports new onset pain at a new location even though the previous pain is well controlled. What will the provider suspect is the cause of this latest report of pain Infection or metastasis A pt reports “burning & shooting” foot pain alternating w/sensations of numbness. Which med will the provider discuss w/the pt Imipramine A pt dx w/ c. difficile infec is considered a high risk for recurrence. Which med will the provider precribe Bezlotoxumab The provider can prescribe a monoclonal antibody med for the pt w/which condition Psoriatic arthritis Which conditions may be treated w/monoclonal antibody (mAb) therapy Breast cancer, hemophilia, asthma, migraines A provider prescribing pain med to each pt, will be most concerned about which pt developing a substance use disorder A pt whose hx indicates the use of prescription narcotic analgesics for back & headache pain What is the provider’s ideal goal of drug rehabilitation Abstinence from the drug The provider is discussing the management of prescribed, controlled substances w/a pt. Which statement by the pt indicates understanding of the information provided “Prescriptions for drugs in Scheduled III & IV may be written to include up to 5 refills” A pt w/alcohol abuse disorder is admitted to the hospital for surgery. The provider is most concerned when the admission interview determines the pt regularly used what med Acetaminophen A young unresponsive adult is brought ot the ED by friends, who report, “He drank more than half of a large bottle of whiskey 3hr ago” Assessment reveals a blood alcohol level of 0.32%. The vital signs are BP 88/32, RR 6/min, Temp 96.8f, P 76/min & weak & thready. The provider will order which intervention to best minimize the pt’s risk of renal failure Gastric lavage & dialysis A pregnant pt is afraid she may have harmed her fetus by consuming alcohol. What is the appropriate response by the provider Determining how much alcohol she consumed & at which stage of her pregnancy A pt w/decreased responsiveness arrivs by ambulance following a night of binge- drinking. The pt exhibits slurred speech & hand tremors. After receiving reports that the pt’s blood alcohol level is 0.4%, the provider beings prep for what event Providing mechanical ventilation & oxygen to manage respiratory depression A pt’s admission hx confirms a habit of daily drinking for several yrs. When questioned further by the provider, the pt reports drinking up to 5 or 6 drinks each day. What action will the provider prioritize Ordering a liver function study A pt who just found out she is prego requests pharmacologic aids to help her quit smoking. The provider will give her what info Nicotine replacement therapy is not w/o its risks, but it’s safer than smoking, so it can be used A pt w/a desire to stop smoking asks a provider about nicotine chewing gum. The pt currently smokes 30 cigarettes/day. What instructions will the provider give the pt Use the 4mg strength gum & chew 1 piece every 2-3hrs A nurse is preparing to give an antibiotic to a pt who reports being allergic to antibiotics. Before giving the med, it’s important for the nurse to do what Ask whether the pt has taken this antibiotic for other infections A pt is taking a drug that has known toxic side effects. What will the nurse do Monitor the function of all organs potentially affected by the drug A nursing student is preparing to give a med that has a black box warning. The student asks the nurse what this means. What will the nurse explain about black box warning They alert prescribers of ways to mitigate potential harm from side effects A pt has taken levodopa for Parkinson’s disease for 2 wks but reports not improvement in the symp. Which response by the nurse is correct A full therapeutic response w/levodopa may take several months to develop. Until the true effect of the dose is seen, it’s not necessary to change to another drug, increase the dose, or change the drug regiment A nurse provides teaching for apt who is newly dx w/Parkinson’s disease. Which statement by the pt indicates understanding of the drug therapy for this disease Levodopa combined w/carbidopa is the initial drug of choice to tx motor symp. A pt newly dx w/Parkinson’s has been taking levodopa/carbidopa for several wks & complains of N/V. The nurse tells the pt to discuss what w/the provider Taking a lower dose w/a low-protein snack A nurse is discussing motor symp w/a pt w/Parkinson’s who has been taking levodopa/carbidopa for 9mo & who is now having regular tics. Which statement by the pt indicates understanding of this sympt “I may need to try a lower dose of levodopa/carbidopa to reduce my tics” (levodopa can cause movement disorders, generally within the 1st yr of therapy)

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NURS 657 PHARMACOLOGY WEEK 1 AND 2 STUDY GUIDE – DOWNLOAD TO ATTAIN AN A+

• A patient diagnosed with chronic pain calls to request an oxycodone (Oxycontin) refill.
Which action should the prescriber take initially?
o Arrange to schedule an appt w/the pt
• A metered-dose albuterol inhaler is prescribed for asthma management. The patient reports
feeling jittery sometimes when taking the medication, and does not feel that the medication is
always effective. Which action will the provider take to best minimize patient risks and
maximize medication effectiveness?
o Auscultate the pt’s lung sounds & obtain other relevant vital signs
• A patient reports that a medication prescribed for recurrent migraine headaches is not
working. Which action is the prescriber’s priority when addressing the patient's concern?
o Ask the pt about the number & frequency of tablets taken
• The drug manual states that older adult patients are at increased risk for hepatotoxicity.
Which action is most important when prescribing this medication to an 80-year-old patient?
o Obtaining baseline liver function studies
• A patient with bipolar disorder is prescribed daily lithium. Which action is most important
for the provider to take in order to determine if the therapeutic level is maintained?
o Order periodic lab testing
• Which factor best supports an increase for full prescriptive authority for both advanced
practice registered nurses (APRNs) and physician assistants (PAs)?
o More pts will have access to health care
• Which prescriber action will have the greatest impact on the patient’s commitment to
adherence to any type of medication therapy?
o Providing med education that the pt can easily understand
• Which patient statement suggests to the provider that the patient’s nonadherence with their
medication plan is related to dissatisfaction with the therapy?
o “I’ve been taking this med for well over a week & I lost only a half a pound”
• How can the prescriber’s regular collaboration with a pharmacist improve positive outcomes
for patients? (Select all that apply.)
o Pharmacists have additional info on drug interaction
o Pharmacists can suggest adequate med dosing
o Pharmacists have firsthand knowledge of the facility formulary
• Which statements made by the prescriber demonstrate an understanding of effective
medication education? (Select all that apply.)
o “This med needs to be stored in the fridge”
o “Take 3 tabs daily: 1 w/breakfast, 1 w/lunch, & 1 w/dinner”
o “You need to take the med as we discussed until all the tabs are gone”
o “Call the office immediately if you begin experiencing any itching, HA, or difficulty
breathing”
• The patient who has been prescribed lithium for a diagnosis of bipolar disorder asks why
blood tests are required on a regular basis. Which provider responses demonstrate an
understanding of why the patient requires a variety of laboratory tests? (Select all that apply.)
o “We need to monitor how your thyroid is functioning”
o “We need to monitor kidney function while you’re on this drug”
o “This med can cause you to lose Na, so we need to measure Na levels”

, • When prescribing drugs with a narrow therapeutic index, what intervention does the provider
take to decrease risk to the patient?
o Monitor the pt’s plasma drug levels at regular intervals
• A patient reports that a medication no longer effectively alleviates symptoms. What process
informs the provider’s response to the patient’s concerns?
o Desensitization of receptor sites results from continual exposure to the drug
• A patient reports that Brand X tablets work faster than Brand Y tablets of the same amount of
the same drug. Which statement informs the prescriber’s response when explaining this
phenomenon to the patient?
o Inactive ingredients used in the composition can result in differing rates of
dissolution, which can alter the drug’s onset of action
• A patient receiving intravenous gentamicin has a toxic serum drug level. The prescriber
confirms that the dosing is correct. Which possible cause of this situation will the provider
explore?
o Whether pt is taking a med that binds to serum albumin
• A patient takes a drug that is metabolized by CYP3A4 isoenzymes. If a CYP3A4 inducing
drug is prescribed, what drug adjustment may be necessary to maintain a therapeutic level of
CYP3A4 substrate?
o Increase dosage of the CYP3A4

• What instructions should the provider give regarding
alcohol intake while taking hydrocodone with acetaminophen for postsurgical pain?
• “You should avoid drinking alcohol while you are taking
the pain med I’ve ordered”
• Which order for furosemide is written appropriately by the
prescriber?
• Furosemide [Lasix] 20mg PO daily
• What action should the prescriber take to minimize the
potential risk of a drug-induced Parkinson-like syndrome?
• Thoroughly educate the pt about recognizing such symp &
the need to notify the office immediately
• What instructions should the provider give when a patient
reports mild nausea after taking a newly approved medication that does not list nausea as a known side
effect?
• “Take the next dose w/food & call the office if the nausea
reoccurs or if other symp develop”
• What medication-induced effect would lead the prescriber
to discontinue a newly prescribed medication in a patient who develops shortness of breath shortly after
taking the initial dose?
• A side effect
• What response should the provider give when asked by a
patient about the purpose of genetic testing before prescribing a medication?
• “Testing will tell us how quickly your body is likely to
metabolize or process the drug”
• What does the provider suspect is responsible for a patient
taking more than the prescribed dosage of a narcotic analgesic for chronic pain for several months?

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