Immunology Lab Quiz 9: Aim CRP Test
C-Reactive Protein (CRP) correct answers 5 identical subunits held together by non-
covalent bonds
CRP has trace constituent of what? correct answers Serum
* originally thought to be an antibody to the c-polysaccharide of pneumococci
Where is CRP primarily synthesized? correct answers The liver
CRP action: correct answers - Opsonization
- Agglutination
- Precipitation
- Activation of complement by classical pathway
* Action is similar to that of an antibody but not specific
What is most widely used marker of acute inflammation? correct answers CRP
What is the time of rapid increase following infection, surgery, or physical trauma to the
body? correct answers 4-6 hours
How much can it be an increase after initial rapid increase? What is the time? correct
answers 100-1000 fold increase; levels peak within 24-72 hours
Common markers of inflammation correct answers - Pain
- Heat
- Redness
- Swelling (edema)
Conditions with expected elevated levels of CRP: correct answers - Heart disease and
myocardial infarction (heart attack)
- Bacterial and viral infections
- TB
- Autoimmune diseases - RA and SLE
- Collagen diseases - scleroderma
- Malignant diseases (cancer)
Is latex agglutination qualitative or quantitative? correct answers - Qualitative
* semi-quantitative determination of CRP in non-diluted serum
Latex particle is coated with what? correct answers Anti-CRP
C-Reactive Protein (CRP) correct answers 5 identical subunits held together by non-
covalent bonds
CRP has trace constituent of what? correct answers Serum
* originally thought to be an antibody to the c-polysaccharide of pneumococci
Where is CRP primarily synthesized? correct answers The liver
CRP action: correct answers - Opsonization
- Agglutination
- Precipitation
- Activation of complement by classical pathway
* Action is similar to that of an antibody but not specific
What is most widely used marker of acute inflammation? correct answers CRP
What is the time of rapid increase following infection, surgery, or physical trauma to the
body? correct answers 4-6 hours
How much can it be an increase after initial rapid increase? What is the time? correct
answers 100-1000 fold increase; levels peak within 24-72 hours
Common markers of inflammation correct answers - Pain
- Heat
- Redness
- Swelling (edema)
Conditions with expected elevated levels of CRP: correct answers - Heart disease and
myocardial infarction (heart attack)
- Bacterial and viral infections
- TB
- Autoimmune diseases - RA and SLE
- Collagen diseases - scleroderma
- Malignant diseases (cancer)
Is latex agglutination qualitative or quantitative? correct answers - Qualitative
* semi-quantitative determination of CRP in non-diluted serum
Latex particle is coated with what? correct answers Anti-CRP
