CHAPTER 10: DRUGS FOR CENTRAL NERVOUS
SYSTEM PROBLEMS VISOVSKY: INTRODUCTION TO
CLINICAL PHARMACOLOGY, 10TH EDITION
QUESTIONS AND ANSWERS GRADED A+
1. tWhich tneurotransmitter thas tan tinhibitory taction twithin tthe tCNS?
a. tEpinephrine
t
b. tAcetylcholine
c. tNorepinephrine
d. tGamma-aminobutyric tacid t- td. tGamma-aminobutyric tacid
2. tA t73-year-old tmale tpatient tnewly tdiagnosed twith tParkinson's tdisease t(PD) tis tprescribed ta
tdopamine tagonist. tThe tpatient's twife tasks tyou tto texplain thow tthis tclass tof tdrugs twill twork tto thelp
ther thusband. tWhat tis tyour tbest tresponse?
a. t"Dopamine tagonists treduce tlevels tof tacetylcholine tto trestore tgait tand tbalance."
b. t"Dopamine tagonists tuse tan tenzyme tto tbreak tdown tdopamine tto timprove tPD tsymptoms." t
c. t"Dopamine tagonists tprevent tthe tbuildup tof tbeta tamyloid tplaques tto timprove tcoordination." td.
t"Dopamine tagonists treduce tmuscle trigidity tand ttremors tby tincreasing tdopamine tlevels." t- td.
t"Dopamine tagonists treduce tmuscle trigidity tand ttremors tby tincreasing tdopamine tlevels."
3. tA tpatient tplaced ton tthe tdrug ttolcapone t(Tasmar) tfor tthe trelief tof tsymptoms tof tParkinson's tdisease
tasks tyou thow tthis tdrug tworks tfor tthe tdisease. tWhat tis tyour tbest tresponse?
a. t"Tolcapone tacts tas ta tdopamine tagonist, treplacing tthe tactivity tof tdopamine."
b. t"Tolcapone tforces tthe tsubstantia tnigra tto tincrease tproduction tof tnatural tdopamine." tc. t"Tolcapone
tsuppresses tthe tenzyme tthat tbreaks tdown tnaturally toccurring tdopamine." td. t"Tolcapone tincreases
tthe tnumber tof tdopamine treceptors tsites." t- tc. t"Tolcapone tsuppresses tthe tenzyme tthat tbreaks tdown
tnaturally toccurring tdopamine."
4. tWhy tare tcarbidopa tand tlevodopa tusually tgiven ttogether?
a. tCarbidopa tis ta tdopamine tagonist tand tlevodopa tis ta tdopamine tantagonist. t
b. tLevodopa tis ta tdopamine tagonist tand tcarbidopa tis ta tdopamine tantagonist. t
c. tCarbidopa tenhances tthe taction tof tlevodopa, tand tless tdrug tis tneeded.
, d. tLevodopa treverses tor tprevents tthe tside teffects tof tcarbidopa. t- tc. tCarbidopa tenhances tthe taction
tof tlevodopa, tand tless tdrug tis tneeded.
5. tWhen tassessing ta tpatient twith tParkinson's tdisease twho ttakes ta tcarbidopa/levodopa tcombination
tdrug, tyou tfind tthat the tnow thas talmost tconstant tmuscle tmovements tthat tlook tlike tuncoordinated
tdancing. tWhat tis tyour tbest taction?
a. tDocument tthe tfinding tas tthe tonly taction.
b. tHold tthe tnext tdrug tdose tand treport tthe tfinding tto tthe thealthcare tprovider.
c. tGive tthe tnext tdose tearlier tthan tscheduled tbecause tthe tdrugs tare twearing toff.
d. tRequest tthat tthe thealthcare tprovider tprescribe ta tone-time tdose tof ta tmuscle trelaxant. t- tb. tHold
tthe tnext tdrug tdose tand treport tthe tfinding tto tthe thealthcare tprovider.
6. tA tpatient tnewly tdiagnosed twith tParkinson's tdisease tis tprescribed tan toral tdopamine tagonist.
tWhich tprecaution tis tmost timportant tto tteach tthe tpatient tand tfamily tabout tthe ttiming tfor ttaking tthis
tdrug?
a. t"Take tthe tdrug t30 tto t60 tminutes tbefore tmeals ton tan tempty tstomach." t
b. t"Take tthe tdrug t30 tto t60 tminutes tafter teating ta thigh tprotein tmeal."
c. t"Take tthe tdrug tfirst tthing tin tthe tmorning tbefore tgetting tout tof tbed."
td. t"Take tthe tdrug twhen tyour tsymptoms tare tat ttheir tworst." t- ta. t"Take tthe tdrug t30 tto t60 tminutes
tbefore tmeals ton tan tempty tstomach."
7. tYou tare tassessing tthe tdrug tlist tof ta tpatient twho thas tbeen tstarted ton ta tdopamine tagonist. tYou
tdiscover tthe tpatient tis talso ttaking tan toral tantihypertensive tdrug. tWhich tof tthe tfollowing tstatements
tshould tyou tmake tto tthis tpatient?
a. t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tincrease tyour tblood tpressure." tb.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tdecrease tyour tblood tpressure." tc.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill thave tno tadverse teffects."
d. t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill treduce tyour tdopamine tlevels." t- tb.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tdecrease tyour tblood tpressure."
8. tA tpatient twith tdiagnosed tParkinson's tdisease tis tprescribed ta tmonoamine toxidase ttype tB tinhibitor
treports tnot tadhering tto ta ttyramine-restricted tdiet. tWhat tsigns/symptoms twould tyou texpect tthis
tpatient tto tpresent twith?
a. tHypertension
b. tSevere tbradycardia
c. tBone tmarrow tfailure
d. tEdema tof tthe tlower textremities t- ta. tHypertension
SYSTEM PROBLEMS VISOVSKY: INTRODUCTION TO
CLINICAL PHARMACOLOGY, 10TH EDITION
QUESTIONS AND ANSWERS GRADED A+
1. tWhich tneurotransmitter thas tan tinhibitory taction twithin tthe tCNS?
a. tEpinephrine
t
b. tAcetylcholine
c. tNorepinephrine
d. tGamma-aminobutyric tacid t- td. tGamma-aminobutyric tacid
2. tA t73-year-old tmale tpatient tnewly tdiagnosed twith tParkinson's tdisease t(PD) tis tprescribed ta
tdopamine tagonist. tThe tpatient's twife tasks tyou tto texplain thow tthis tclass tof tdrugs twill twork tto thelp
ther thusband. tWhat tis tyour tbest tresponse?
a. t"Dopamine tagonists treduce tlevels tof tacetylcholine tto trestore tgait tand tbalance."
b. t"Dopamine tagonists tuse tan tenzyme tto tbreak tdown tdopamine tto timprove tPD tsymptoms." t
c. t"Dopamine tagonists tprevent tthe tbuildup tof tbeta tamyloid tplaques tto timprove tcoordination." td.
t"Dopamine tagonists treduce tmuscle trigidity tand ttremors tby tincreasing tdopamine tlevels." t- td.
t"Dopamine tagonists treduce tmuscle trigidity tand ttremors tby tincreasing tdopamine tlevels."
3. tA tpatient tplaced ton tthe tdrug ttolcapone t(Tasmar) tfor tthe trelief tof tsymptoms tof tParkinson's tdisease
tasks tyou thow tthis tdrug tworks tfor tthe tdisease. tWhat tis tyour tbest tresponse?
a. t"Tolcapone tacts tas ta tdopamine tagonist, treplacing tthe tactivity tof tdopamine."
b. t"Tolcapone tforces tthe tsubstantia tnigra tto tincrease tproduction tof tnatural tdopamine." tc. t"Tolcapone
tsuppresses tthe tenzyme tthat tbreaks tdown tnaturally toccurring tdopamine." td. t"Tolcapone tincreases
tthe tnumber tof tdopamine treceptors tsites." t- tc. t"Tolcapone tsuppresses tthe tenzyme tthat tbreaks tdown
tnaturally toccurring tdopamine."
4. tWhy tare tcarbidopa tand tlevodopa tusually tgiven ttogether?
a. tCarbidopa tis ta tdopamine tagonist tand tlevodopa tis ta tdopamine tantagonist. t
b. tLevodopa tis ta tdopamine tagonist tand tcarbidopa tis ta tdopamine tantagonist. t
c. tCarbidopa tenhances tthe taction tof tlevodopa, tand tless tdrug tis tneeded.
, d. tLevodopa treverses tor tprevents tthe tside teffects tof tcarbidopa. t- tc. tCarbidopa tenhances tthe taction
tof tlevodopa, tand tless tdrug tis tneeded.
5. tWhen tassessing ta tpatient twith tParkinson's tdisease twho ttakes ta tcarbidopa/levodopa tcombination
tdrug, tyou tfind tthat the tnow thas talmost tconstant tmuscle tmovements tthat tlook tlike tuncoordinated
tdancing. tWhat tis tyour tbest taction?
a. tDocument tthe tfinding tas tthe tonly taction.
b. tHold tthe tnext tdrug tdose tand treport tthe tfinding tto tthe thealthcare tprovider.
c. tGive tthe tnext tdose tearlier tthan tscheduled tbecause tthe tdrugs tare twearing toff.
d. tRequest tthat tthe thealthcare tprovider tprescribe ta tone-time tdose tof ta tmuscle trelaxant. t- tb. tHold
tthe tnext tdrug tdose tand treport tthe tfinding tto tthe thealthcare tprovider.
6. tA tpatient tnewly tdiagnosed twith tParkinson's tdisease tis tprescribed tan toral tdopamine tagonist.
tWhich tprecaution tis tmost timportant tto tteach tthe tpatient tand tfamily tabout tthe ttiming tfor ttaking tthis
tdrug?
a. t"Take tthe tdrug t30 tto t60 tminutes tbefore tmeals ton tan tempty tstomach." t
b. t"Take tthe tdrug t30 tto t60 tminutes tafter teating ta thigh tprotein tmeal."
c. t"Take tthe tdrug tfirst tthing tin tthe tmorning tbefore tgetting tout tof tbed."
td. t"Take tthe tdrug twhen tyour tsymptoms tare tat ttheir tworst." t- ta. t"Take tthe tdrug t30 tto t60 tminutes
tbefore tmeals ton tan tempty tstomach."
7. tYou tare tassessing tthe tdrug tlist tof ta tpatient twho thas tbeen tstarted ton ta tdopamine tagonist. tYou
tdiscover tthe tpatient tis talso ttaking tan toral tantihypertensive tdrug. tWhich tof tthe tfollowing tstatements
tshould tyou tmake tto tthis tpatient?
a. t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tincrease tyour tblood tpressure." tb.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tdecrease tyour tblood tpressure." tc.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill thave tno tadverse teffects."
d. t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill treduce tyour tdopamine tlevels." t- tb.
t"Taking tan tantihypertensive tand ta tdopamine tantagonist twill tdecrease tyour tblood tpressure."
8. tA tpatient twith tdiagnosed tParkinson's tdisease tis tprescribed ta tmonoamine toxidase ttype tB tinhibitor
treports tnot tadhering tto ta ttyramine-restricted tdiet. tWhat tsigns/symptoms twould tyou texpect tthis
tpatient tto tpresent twith?
a. tHypertension
b. tSevere tbradycardia
c. tBone tmarrow tfailure
d. tEdema tof tthe tlower textremities t- ta. tHypertension
