Aphon Principles Of Chemo And Biotherapy Test
Latest Update
1. Biotherapy Targeted anticancer agents also known as biological re-
sponse modifiers (BRM)
2. Tyrosine kinase Biotherapy
inhibitors (TKIs)
are what class
3. Monoclonal anti- Biotherapy
bodies (MoAbs)
are what class
4. Define pharma- Study of drug absorption, metabolism, and excretion
cokinetics
5. Define pharma- The concentration of the drug in the body and how it
codynamics produces a response
6. Define adjuvant The use of chemo after another type of therapy, such as
chemotherapy surgery, to treat residual disease or undetectable metas-
tasis.
7. Define neoadju- When chemo is used preoperatively to decrease tumor
vant chemothera- burden in order to make it easier to remove the tumor
py surgically.
8. Define sanctuary Sites within the body where tumor cells sequester and are
sites not easily reached by chemo such as the CNS
9. What normal Hematopoietic, mucosal (mouth & GI), hair follicles
cells are most of-
ten effected by
chemotherapy
10. Why use To prevent cancer cells from dividing, metastasizing, and
chemotherapy ultimately causing the death of the patient
11. Cure To permanently eradicate the cancer
12. Control To extend the length & QOL when cure is not feasible or
realistic
1/7
, Aphon Principles Of Chemo And Biotherapy Test
Latest Update
13. Palliation Minimize pain and suffering during end of life
14. Resting phase of Gap 0 - cells not dividing
cell cycle
15. Postmitotic Gap 1 - enzymes needed for DNA synthesis are produced,
phase protein and RNA synthesis takes place (18 Hours)
16. Synthesis (S) Cellular DNA duplicated (20 hours)
Phase
17. Premitotic phase Gap 2 - both protein and RNA synthesis occur, precursors
of mitotic spindle are produced. Shortest phase
18. Mitosis (M) Cell division occurs in 4-step phase (prophase,
Phase metaphase, anaphase, telophase) 1 Hour
19. 5 stages of repro- Resting, Postmitotic, synthesis, premitotic, mitosis
duction of cells
20. Cell Cycle time The amount of time it takes a cell to move from one mitotic
episode to another.
21. Cell-cycle-specif- Those drugs that work only when cells are in a specific
ic agents phase of the cell cycle.
22. Doubling time The time required for a tumor mass to reach a certain size
or double in size.
23. Growth fraction Percentage of cells actively dividing at any given point in
time.
24. Tumor burden Size of the tumor as determined by the number of cells
present.
25. A higher growth Results in a higher cell kill with exposure to cell cycle
fraction specific agents.
26.26.
2/7
Latest Update
1. Biotherapy Targeted anticancer agents also known as biological re-
sponse modifiers (BRM)
2. Tyrosine kinase Biotherapy
inhibitors (TKIs)
are what class
3. Monoclonal anti- Biotherapy
bodies (MoAbs)
are what class
4. Define pharma- Study of drug absorption, metabolism, and excretion
cokinetics
5. Define pharma- The concentration of the drug in the body and how it
codynamics produces a response
6. Define adjuvant The use of chemo after another type of therapy, such as
chemotherapy surgery, to treat residual disease or undetectable metas-
tasis.
7. Define neoadju- When chemo is used preoperatively to decrease tumor
vant chemothera- burden in order to make it easier to remove the tumor
py surgically.
8. Define sanctuary Sites within the body where tumor cells sequester and are
sites not easily reached by chemo such as the CNS
9. What normal Hematopoietic, mucosal (mouth & GI), hair follicles
cells are most of-
ten effected by
chemotherapy
10. Why use To prevent cancer cells from dividing, metastasizing, and
chemotherapy ultimately causing the death of the patient
11. Cure To permanently eradicate the cancer
12. Control To extend the length & QOL when cure is not feasible or
realistic
1/7
, Aphon Principles Of Chemo And Biotherapy Test
Latest Update
13. Palliation Minimize pain and suffering during end of life
14. Resting phase of Gap 0 - cells not dividing
cell cycle
15. Postmitotic Gap 1 - enzymes needed for DNA synthesis are produced,
phase protein and RNA synthesis takes place (18 Hours)
16. Synthesis (S) Cellular DNA duplicated (20 hours)
Phase
17. Premitotic phase Gap 2 - both protein and RNA synthesis occur, precursors
of mitotic spindle are produced. Shortest phase
18. Mitosis (M) Cell division occurs in 4-step phase (prophase,
Phase metaphase, anaphase, telophase) 1 Hour
19. 5 stages of repro- Resting, Postmitotic, synthesis, premitotic, mitosis
duction of cells
20. Cell Cycle time The amount of time it takes a cell to move from one mitotic
episode to another.
21. Cell-cycle-specif- Those drugs that work only when cells are in a specific
ic agents phase of the cell cycle.
22. Doubling time The time required for a tumor mass to reach a certain size
or double in size.
23. Growth fraction Percentage of cells actively dividing at any given point in
time.
24. Tumor burden Size of the tumor as determined by the number of cells
present.
25. A higher growth Results in a higher cell kill with exposure to cell cycle
fraction specific agents.
26.26.
2/7
