LYMPHADENOPATHY
Neoplastic Non-neoplastic (Inflammation)
Reactive Lymphadenitis
Primary (Lymphoma) Secondary (Metastatic Carcinoma)
Caused By infection or cellular dipris
Hodgkin's Non-Hodgkin's The 1ry tumor may be occult and seed into L.N, CD
45, and diagnosed by Immunoperoxidase
Technique.
Acute Chronic
Reed-Sternberg cells are neoplastic, Curable, systematic More common in mature cells, Always Malignant,
manifestations as fever, Spreadable, variable Maybe indolent or aggressive, Monoclonal release
inflammatory cells (PNLs), expresses CD 30 Terminal Deoxytransferase, B > T, Effacement and
Non-specific Suppporative Specific Non-Specific
matted, Fish flesh.
Classical HL Nodular Lymphocyte Predominant HL
Tissue is still not fully damaged, Throbbing, Due to Bacterial Tuberculosis Sarcoidosis Follicolar Hyperplasia Paracortical Hyperplasia Sinus Hyperplasia Mixed Hyperplasia
B cell (CD 10,19,20) T cell (CD 2,3,4,7,8)
Congested, tender, Large germinal toxins Drainage, PNL
centers, PNL
Nodular Sclerosis Mixed Cellularity Lymphocyte Rich Lymphocyte Depleted Popcorn Appearance, Lack CD 15,30 has its own B
Epithelioid, Langhans, Fibrosis, if lung => Hillar , Non-Caseating, Epithelioid, Langhan's, In L.N. Cortex, Activate Humoral I.R. (B cells), Large Proliferation of Paracortex, CMI (T cells), Infectious Draining Cancer, ex: Axillary and breast cancer Combines all of them
Ags, Most indolent, Vague nodular pattern, Indolent (Low grade) Aggressive (High grade) Anaplastic large
Matted, Soft cold Caseation, horseshoe, necrosis Shawmann and Asteroid Bodies. Angiotensin Germinal center, Vary in size, Light zone mononucleosis (EBV)
Inflammatory background lacks Eosinophils and
Converting Enzyme Proliferation Preserved Architecture, increased
plasma, EBV is -ve
central centrocyte
Nodular surrounded by Fibrosis, Lacunar variants, Mixed inflammatory, lacks collagen and Recently added, Abundant small lymphocytes. Least Common CHL type, No background, HIV
70% of CHL, ages 20-30, doesn't express specific T associated with EBV related, Middle to elderly aged men. Follicular Diffuse large Burkitt's (extra nodal) Bimodal (Age extremities), Large atypical Kidney
or B Ags only CD 15,30 , Collagen bands and or horse shoe appearance, CD 30, involve t(2;5),
Mediastinal involvement. ALK positive has good prognosis and vice versa.
Follicular proliferations, nodular appearance, Most important in adults, 50% NHL, Round Most Common in Childhood, Infected virally (EBV),
Normal germinal B cells but neoplastic irregular and cleaved B cells resemble Maybe: Endemic (Africa), Sporadic (Cosmopolitan),
Centrocyte -Larger and cleaved nuclei with dense Centroblasts and immunoblasts, Very large and Immunodeficiency Associated (HIV), CNS involvement
chromatin- express BCL2, not easily curable, aggressive, Express Ags: CD 19,20,79a Risk, High apoptotic and neoplastic cells with light
progress to Diffuse large. macrophages in Background "Starry Sky pattern",
Shows CD 19,20,22 ,CD 10 and High Ki67, MYC gene on
chr.8 karyotyping.
Neoplastic Non-neoplastic (Inflammation)
Reactive Lymphadenitis
Primary (Lymphoma) Secondary (Metastatic Carcinoma)
Caused By infection or cellular dipris
Hodgkin's Non-Hodgkin's The 1ry tumor may be occult and seed into L.N, CD
45, and diagnosed by Immunoperoxidase
Technique.
Acute Chronic
Reed-Sternberg cells are neoplastic, Curable, systematic More common in mature cells, Always Malignant,
manifestations as fever, Spreadable, variable Maybe indolent or aggressive, Monoclonal release
inflammatory cells (PNLs), expresses CD 30 Terminal Deoxytransferase, B > T, Effacement and
Non-specific Suppporative Specific Non-Specific
matted, Fish flesh.
Classical HL Nodular Lymphocyte Predominant HL
Tissue is still not fully damaged, Throbbing, Due to Bacterial Tuberculosis Sarcoidosis Follicolar Hyperplasia Paracortical Hyperplasia Sinus Hyperplasia Mixed Hyperplasia
B cell (CD 10,19,20) T cell (CD 2,3,4,7,8)
Congested, tender, Large germinal toxins Drainage, PNL
centers, PNL
Nodular Sclerosis Mixed Cellularity Lymphocyte Rich Lymphocyte Depleted Popcorn Appearance, Lack CD 15,30 has its own B
Epithelioid, Langhans, Fibrosis, if lung => Hillar , Non-Caseating, Epithelioid, Langhan's, In L.N. Cortex, Activate Humoral I.R. (B cells), Large Proliferation of Paracortex, CMI (T cells), Infectious Draining Cancer, ex: Axillary and breast cancer Combines all of them
Ags, Most indolent, Vague nodular pattern, Indolent (Low grade) Aggressive (High grade) Anaplastic large
Matted, Soft cold Caseation, horseshoe, necrosis Shawmann and Asteroid Bodies. Angiotensin Germinal center, Vary in size, Light zone mononucleosis (EBV)
Inflammatory background lacks Eosinophils and
Converting Enzyme Proliferation Preserved Architecture, increased
plasma, EBV is -ve
central centrocyte
Nodular surrounded by Fibrosis, Lacunar variants, Mixed inflammatory, lacks collagen and Recently added, Abundant small lymphocytes. Least Common CHL type, No background, HIV
70% of CHL, ages 20-30, doesn't express specific T associated with EBV related, Middle to elderly aged men. Follicular Diffuse large Burkitt's (extra nodal) Bimodal (Age extremities), Large atypical Kidney
or B Ags only CD 15,30 , Collagen bands and or horse shoe appearance, CD 30, involve t(2;5),
Mediastinal involvement. ALK positive has good prognosis and vice versa.
Follicular proliferations, nodular appearance, Most important in adults, 50% NHL, Round Most Common in Childhood, Infected virally (EBV),
Normal germinal B cells but neoplastic irregular and cleaved B cells resemble Maybe: Endemic (Africa), Sporadic (Cosmopolitan),
Centrocyte -Larger and cleaved nuclei with dense Centroblasts and immunoblasts, Very large and Immunodeficiency Associated (HIV), CNS involvement
chromatin- express BCL2, not easily curable, aggressive, Express Ags: CD 19,20,79a Risk, High apoptotic and neoplastic cells with light
progress to Diffuse large. macrophages in Background "Starry Sky pattern",
Shows CD 19,20,22 ,CD 10 and High Ki67, MYC gene on
chr.8 karyotyping.
