1. Which two main agencies oversee the enforcement of federal regulations? The United States
Department of Agriculture (USDA) and the Public Health Service (PHS) enforces federal regulations on
animal welfare.
2. What is the purpose of the Guide for the Care and Use of Laboratory Animals? It assists investigators
in fulfilling their obligation to plan and conduct animal experiments in accordance with the highest
scientific, humane, and ethical principles.
3. What is required for research protocols? All research protocols must be approved by an Institutional
Animal Care and Use Committee (IACUC).
4. Which occupational health and safety concerns are relevant to performing research on rabbits? Risks
for scratch injuries, developing an allergy or asthma, and participation in the institution's occupational
health and safety program.
5. What is the purpose of the alternatives search in an animal protocol? To search for procedures that
may replace the use of animals, reduce the number of animals used, or refine methodology to minimize
animal pain or distress.
6. What information should be provided with the results of a database search for alternatives? The
names of databases used, date of search, years of citations accessed, and search strategy.
7. What are an investigator's responsibilities towards laboratory animals? Assuring that staff are
properly trained to perform animal procedures humanely, provide necessary supportive care during and
after procedures, and ensure experimentation is delayed until quarantine.
8. What happens when rabbits have a moderately painful condition? They may appear normal or have
subtle changes in activity level.
9. What is true regarding the assessment of pain or distress in rabbits? It can be subtle and not always
immediately apparent.