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Extracellular Matrix (ECM) Components Questions And Answers With Latest Updates
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Glycosaminoglycans (GAGs) - -Unbranched - (-) Charged polysaccharide chains Proteoglycans - 95% sugar -Large Molecules that provide: Cushion and physical barriers -Synthesized in ER or plasma membrane -Release from cell or bound to membrane Fibrous Proteins (Collagens) - Maintain tissue integrity Form bone, teeth Organized to resist shear stress: Tendons, Ligaments, Skin, Cartilage Elastin - Provide elasticity: Digestive tract, Vasculature, Bladder, Uterus Glycoproteins - Short Unbranched Less sugar than proteoglycans Facilitate cell attachment Fibronectin: Binds collagen, proteoglycan, integrin Integrin: Binds to actin (for signaling), tissue integrity
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