NON-SPECIFIC DRUG ACTION
By virtue of their physicochemical properties
Activated charcoal
Osmotic diuretics
FALSE SUBSTRATES/INHIBITORS FOR CERTAIN
TRANSPORT SYSTEMS
Ion channels
Ca2+ = calcium channel blockers
Na+ = local anesthetics
KATP = oral antidiabetics
Active transport
Na+/K+-ATPase = cardiac glycosides
ENZYME INHIBITORS
Acetylcholinesterase
HMG-CoA reductase
MAO
COX
Thymidine kinase
Carbonic anhydrase(diuretics)
ACTING ON SPECIFIC PROTEIN MOLECULES (Rs)
MOST drugs
Proteins are located in the cell membrane
Rs respond to endogenous chemicals