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Anxiety and Stress (Neuroscience & Behaviour)

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Full lecture notes for "Anxiety and Stress" lecture in Neuroscience and Behaviour module (C82NAB).

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Anxiety & Stress
Stress: The physiological and psychological state of disruption caused by the presence of an
unanticipated disruptive or stimulating event.

Stressor: Factors or events real or imagined that elicits a stress response

Eustress: stress that adds a positive enhancing dimension to the quality of life

Distress: Stress that diminishes the quality of life commonly associated with disease, maladaption,
illness.

Canon (1914,1932)

- Studied animal’s responses to stressful stimuli
- “fight or flight”
- Under situations of danger, people undergo physiological reactions which prepare the organism
to respond to threat.

Physiological responses to threat

 Pupils dilate – see more clearly
 Hairs stand up on end – make us seem larger, and making us more sensitive to environment
 Heart rate increases and arteries constrict to maximise pressure around the system
 The respiratory system open up and breathing speeds up – gets more air in the system so
increased blood flow can be oxygenated. The blood carries oxygen to the muscles allowing them
to work harder.
 Fat from fatty cells and glucose from the liver are metabolised – creating instant energy
 Blood vessels to the kidney and digestive system constrict – effectively shutting down systems
that are not essential – reduction of saliva in the mouth, bowels and bladder may open up
 Blood vessels to the skin constrict reducing any potential blood loss
 Sweat glands open up, providing an external cooling liquid
 Endorphins are released – reduces pain.

Hypothalamic Pituitary Adrenocortical system (HPA)

1. Corticotropin Releasing factor (CRF) released in response to environmental stressor from
hypothalamus.
2. Adrenocorticotropic hormone (ACTH) is then released by pituitary
3. Which in turn releases cortico –steroids from adrenals.
4. When stressor is terminated – negative feedback occurs, shut down of HPA axis


Seyle’s General Adaption Syndrome
 Found rats reaction to new hormones was the same – general stress response

Stage one: Alarm Reaction:

, - Initial dip – lowered immune system –more susceptible to infection and disease
- Trauma causes immediate set of reactions that combat the stress.
- If stress is not severe or long-lasting, we bounce back and recover rapidly.

Stage Two: Resistance:

- Eventually we adapt to stress and become more resistant to illness and disease.
- Our immune systems works overtime for us during this period, trying to keep up with the
demands placed upon it. We become complacent about our situation and assume we can resist
the dangers of stress indefinitely.

Stage Three: Exhaustion:

- Because our body is not able to maintain homeostasis and the long-term resistance needed to
combat stress, we invariable develop a sudden drop in our resistance level.
- Life sustaining mechanisms slow down, organs systems begin to break down and stress-fighting
reserves finally succumb to “diseases of adaptation”

Strengths

 General theory variety of stressors
 Physiological and environmental interaction
 Physiological mechanism for relationship between stress and illness

Weaknesses:

 Limited role of psychological factors – individual differences
 Assumes responses are uniform
 Considers stress as an outcome


Anxiety
 Diffuse unpleasant vague sense of apprehension often accompanied by autonomic symptoms
 Distinguishable from fear
 State Anxiety: experienced at a particular moment increased by an anxiogenic stimulus
 Trait Anxiety: Enduring feature of an individual doesn’t vary from moment to moment
 DSM identifies 8 subtypes:
1. Panic Disorder
2. Agoraphobia
3. Social phobia
4. Simple phobia
5. OCD
6. PTSD
7. Generalised Anxiety Disorder
8. Unspecified

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