NAPLEX Diabetes Questions with 100% Correct Answers

NAPLEX Diabetes Questions with 100% Correct Answers A1C goal for DM less than 7% preprandial blood glucose goal for DM 80-130 mg/dL Peak postprandial glucose goal in DM 180 mg/dL Drugs that can lower glucose beta blockers, quinolones, linezolid, lorcaserin, pentamide *can also raise Drugs that can raise glucose beta blockers, thiazides, Loops, immunosuppressants (tacrolimus, cyclosporine), ~~~niacin, PIs~~~, quinolones, atypical antipsychotics, statins, systemic steroids If A1C is above _______, may start with dual therapy 8.5% If A1c is 10% or above consider starting insulin If initiating dual therapy and the patient has ASCVD, choose one of the following: GLP1: liraglutided, semaglutide, exenatide SGLT2: empagliflozin, canagliflozin If initiating dual therapy and the patient has HF or CKD, choose one of the following: empagliflozin or canagliflozin if those are not tolerated then use GLP1 (lira-, sem-, or exana-) If initiating dual therapy and the patient has no ASCVD, HF, or CKD consider (three things and their meds): 1. minimize hypoglycemia: DPP-4, GLP1, SGLT2, or TZD 2. weight loss: GLP or SGLT2 3. cost: SU or TZD Three drug combinations that are not recommended insulin with SU or meglitindies Combo injectable therapy basal insulin and either a GLP-1 or mealtime insulin Drugs that lower hepatic glucose output metformin Drugs that raise or replace insulin secretion insulin, sulfonylureas, meglitinides Drugs that lower glucagon (which lowers glucose production) GLP-1, DPP-4, pramlintide Drugs that slow gastric emptying GLP-1, pramlintide Drugs that raise glucose excretion SGLT 2 inhibitors Drugs that increase insulin sensitivity metformin, TZDs metformin & glipizide Metaglip metformin & glyburide Glucovance metformin & pioglitazone Actoplus Met, Actoplus Met XR metformin/alogliptin Kazano metformin/linagliptin Jentadueto metformin/sitagliptin Janumet, Janumet XR metformin/saxagliptin Kombiglyze XR metformin/canagliflozin Invokamet