ILE 3 - Final Exam Questions And Answers 100% Correct (2024 New Update)

ILE 3 - Final Exam Questions And Answers 100% Correct (2024 New Update) I - ANS-biopharm class ___ has a high solubility and high permeability II - ANS-biopharm class ___ has a low solubility and a high permeability III - ANS-biopharm class ___ has a high solubility and a low permeability IV - ANS-biopharm class ___ has a low solubility and a low permeability metoprolol - ANS-example from class of drug in biopharm class I carbamazepine - ANS-example from class of drug in biopharm class II metformin - ANS-example from class of drug in biopharm class III hydrochlorthiazide - ANS-example from class of drug in biopharm class IV 250 - ANS-the difference between high and low solubility of drugs per the biopharm class system is what mL? increase - ANS-ionization (increased water solubility), small particle size, and amorphous particles ___ dissolution excipients - ANS-what factor can increase or decrease dissolution? increase - ANS-Per the Noyes-Whitney Equation, temperature can ___ dissolution rate decrease - ANS-Per the Noyes-Whitney Equation, viscosity can ___ dissolution rate decrease - ANS-Per the Noyes-Whitney Equation, gastric pH can biggest - ANS-solubility and MW have the __ effect on dissolution rate per the NW equation negative - ANS-polar, non-ionizable functional groups have a ___ logP positive - ANS-non-polar function groups have a ___ logP non-polar - ANS-ring structures are ___ (polar or non-polar) do not - ANS-amides, phenols, ethers, alcohols, and ketones are polar functional groups that do/do not ionize? do - ANS-amines, carboxylic acids, and amino acids are polar functional groups that do/do not ionize? hydrophilic - ANS-negative logP scores are considered more hydrophilic OR lipophilic? lipophilic - ANS-positive logP scores are considered more hydrophilic OR lipophilic? hydrophilic - ANS-which type of molecules are more readily disolved? lipophilic - ANS-which type of molecules more readily pass through membranes? Continues...