Physiology Exam 1 - RBC Questions With Correct Answers Correctly Done

What are the 3 main sites of extramedullary hematopoiesis in order of prominence? correct answersSpleen, Liver, Lymph nodes Grossly, bone marrow is either red or yellow. What does each represent? correct answersRed - hematopoietic tissue Yellow - adipose tissue What percentage of marrow cellularity in adult dogs is comprised of morphologically indistinct hematopoietic precursors? correct answersless than 2% What 3 stem cell types can a pluripotent hematopoietic stem cell (HSC) become upon cell division? correct answerslymphoid stem cell, GEMM stem cell, Itself (HSC) what is the name of the earliest erythroid precursor that can be identified morphologically by light microscopy? correct answersRubriblast Regarding O2 sensing and initiation of erythropoiesis: A. what is the oxygen-sensing protein of tissues B. how do tissue oxygen levels regulate its funcion C. with tissue hypoxia, this protein stimulates production of what key hormone of erythropoiesis D. this key hormone is produced primarily in which organ? correct answersA: Hypoxia Inducible Factor's (HIF's) B: If O2 is sufficient - HIF's are hydroxylated (-OH) and destroyed If O2 is insufficient - HIF's are not hydroxylated and form heterodimers that will stimulate the production of EPO C: Erythropoietin (EPO) D: Kindey Name the 4 sequential stages of nucleated RBC precursors that are identifiable microscopically and list them in order of formation. correct answersRubriblast --> Prorubricyte --> Rubricyte --> Metarubricyte Under normal conditions how long does it take for a rubriblast to develop into a mature RBC? correct answers5 days - can take as little as 3 if EPO amplifies the process Describe the cytomorphologic changes that occur in RBC precursors during erythropoiesis in terms of: A. Cell size B. Nuclear size C. Nuclear chromatin D. Cytoplasmic color correct answersA: Cell size goes from large --> small