Lecture 18
Control of Gene Expression
in Eukaryotes
BI333: General Genetics
Dr. Matt Arterburn
Department of Biology
,Control Points for Eukaryotic Genes
cytoplasm Arrangements of genes
in the genome &
& copy
copy ##
nucleus
DNA I. Chromatin Structure &
Chemical Modification
II. Transcription
RNA
III. RNA Processing
mRNA
IV. Nuclear Export
V. Translation
Protein
VI. Protein Modification
& Trafficking
, POSITION EFFECTS OF GENES
• Different regions of the genome have different levels of expression (ex:
heterochromatin and euchromatin)
• Ex: movement of red pigment gene for Drosophila eye color to a region
near heterochromatin
• Lowers pigment gene expression and causes a partial “white eye” mutant
• Cells can control expression
by moving genes to other
regions (their position in the
genome can determine their
expression levels)
• This is used by many
organisms in specific gene
expression strategies
Control of Gene Expression
in Eukaryotes
BI333: General Genetics
Dr. Matt Arterburn
Department of Biology
,Control Points for Eukaryotic Genes
cytoplasm Arrangements of genes
in the genome &
& copy
copy ##
nucleus
DNA I. Chromatin Structure &
Chemical Modification
II. Transcription
RNA
III. RNA Processing
mRNA
IV. Nuclear Export
V. Translation
Protein
VI. Protein Modification
& Trafficking
, POSITION EFFECTS OF GENES
• Different regions of the genome have different levels of expression (ex:
heterochromatin and euchromatin)
• Ex: movement of red pigment gene for Drosophila eye color to a region
near heterochromatin
• Lowers pigment gene expression and causes a partial “white eye” mutant
• Cells can control expression
by moving genes to other
regions (their position in the
genome can determine their
expression levels)
• This is used by many
organisms in specific gene
expression strategies
