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Exam (elaborations)

SBB Hemoglobin and Hemoglobinopathies fully solved 2024

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SBB Hemoglobin and Hemoglobinopathies Hemoglobin tetramer - correct answer 2 alpha like chains 2 beta like chains 4 heme rings with Fe Embryonic hemoglobins - correct answer Hb Gower 1 Hb Gower 2 Hb Portland Fetal Hemoglobin - correct answer Hb F (alpha2, gamma2) Adult hemoglobin - correct answer Hb A (alpha2beta2) Hb A2 (alpha2delta2) Hemoglobin A structure - correct answer -2 alpha and 2 beta globin chains, each with a attached heme ring (Fe in center) Main function of Hb A - correct answer Carry O2 to and CO2 back from tissues. -Binds O2 allosterically -Binds CO2 while releasing O2, and O2 while releasing CO2 -Binds H+ in low pH and releases it in high pH Oxygen-hemoglobin dissociation curve - correct answer Shift to left: alkalosis Shift to right: acidosis Hemoglobin F (alpha2gamma2) - correct answer 65-95% of newborn Hb (adult at 5 years)

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