UNE 1005 Biochem Final Study Set Exam 2024 Questions & Answers 100% Correct!

In the fasted state, fatty acyl-CoA are transported across the mitochondrial membrane. The transport of fatty acids via carnitine palmitoyl transferase I (CPTI) can be directly inhibited by which of the following compounds? - ANSWERSMalonyl CoA Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon will activate which of the following enzymes? - ANSWERSHormone sensitive lipase Glucagon will increase levels of lipolysis through the phosphorylation and activation of hormone sensitive lipase. A 3-day old male is brought to the emergency department by ambulance. He is unconscious on admission. Laboratory analysis of a blood sample shows hypoglycemia and no ketones. Blood spot analysis showed elevation of medium chain acylcarnitines as hexanoyl carnitine (C6), octanoyl carnitine (C8). A urine sample was positive for dicarboxylic acids. This clinical picture is most consistent with a defect in the: - ANSWERSB-oxidation of medium chain fatty acids An 11-year-old female is brought to the emergency department by her father. He reports she has recently been very thirsty and needs to make frequent trips to the bathroom. A rapid dipstick test reveals glucose in her urine and further diagnostics are consistent with a diagnosis of type 1 diabetes. Evaluation of this girl's liver would reveal an increase rate of which of the following processes? - ANSWERSKetogenesis A 3-year-old male is brought to the emergency department by his parents. He is unconscious on admittance and his blood glucose was 15 mg/dl, (normal 75 - 100 mg/dl). Further testing showed this individual had a deficiency in carnitine. Based on this diagnosis you would also expect which of the following to be true with regards to metabolism. - ANSWERSThis patient would have elevated levels of circulating free fatty acids. After an overnight fast, which of the following compounds would be elevated in the blood of a patient with primary carnitine deficiency? - ANSWERSFatty acids Ketogenesis is regulated by the rate of several other processes. Which of the following would decrease the rate of ketone body synthesis? - ANSWERSIncreased flux through the TCA cycle. Glucose cannot be synthesized from the β-oxidation of even chain fatty acids because: - ANSWERSthe acetyl CoA produced from β-oxidation is completely oxidized in the TCA cycle