ibclc - LER pharm fully solved 2024/2025

ibclc - LER pharmthe amount of a drug that passes into a mother's milk depends on - correct answer maternal plasma kinetics protein binding lipid solubility molecular mass/weight bioavailability to the infant half-life in the mother's and infant's blood stream relative infant dose - correct answer generally, less than 10% of a maternal drug dose transfers into the milk, thus to the baby the baby's dose from the milk is calculated based on his weight, and is compared to the mother's daily dose if the baby's RID is less than 10% of the mother's dose the medication is deemed generally safe. maternal plasma kinetics - correct answer drugs transfer from the maternal plasma (capillary) then passes through the alveolar cell wall and the lactocyte into the lumen of the alveoli Protein Binding - correct answer most drugs are transported by a large molecular weight protein in the plasma *the more medication is bound to the plasma protein, the less there is that is floating free in the plasma *as the percentage of drug binding goes up, the level of the drug in the milk goes down Medications that show a high protein binding property should be used as a first choice medications that are high protein binding: antibiotics: doxycycline and clindamycin heart medication: digatoxin Lipid Solubility - correct answer the easier a drug dissolves in fats, the higher the drug levels are in milk