NRNP 6675 WEEK 11 FINAL EXAM LAST EXAM Questions and Answers (Verified Answers).

1. The 1/2 life of lithium is about ANS 24 hours 2. Fluoxetine is the SSRI with the WD risk ANS lowest due to long half life 3. What antipsychotics are good for pts who miss doses of their meds ANS An- tipsychotics with long half-lives: 1. Cariprazine(Vrylar): (2-4 days-active metabolites up to 3 weeks) 2. Abilify (3 days) 3. Brexipiprazole (4 days) 4. Pimozide (4-5 days) 5. Pimavanserin (2 days, active metabolites 8 days) 4. Disulfiram's alcohol interactions persist for up to how long after the med- ication is stopped ANS LONG Half life--2-3 days persist up to 2 weeks following stopping 5. What is the only TCA with a long half life ANS Protriptyline (Vivactil) 6. Most psychotropics have a medium range 1/2 life of approx ANS 24 hours 7. what does "steady state" mean in relation to 1/2 life ANS steady state means that you are eliminating the drug at the same overall rate that you are ingesting it 8. Lithium reaches its 'steady state' when ANS 5 half lives example: Day 1: Start pt on Lithium 600 mg daily Day 2: (24 hours later) the amount left in his body is 300 mg (day 2 min) because 24 hours has passed--one 1/2 life--therefore the pt has excreted 1/2 of the initial amount. THEN the pt takes his 2nd dose of 600 mg on DAY 2-resulting in a max dose of 900 (300 mg left in body + 600 mg of 2nd dose). DAY 3: starts off with 450 mg (1/2 of the 900 mg in pt's system) and after taking the day 3 600 mg dose, the pt now has a total of 1050 mg