BMTCN TEST QUESTIONS WITH
CORRECT ANSWERS
A patient developed type 4 PTLD three years after an allogeneic HSCT. Which of the
following treatment interventions would the nurse expect an order for? -
ANSWER-Aggressive chemotherapy
Red bone marrow produces - ANSWER-hematopoietic stems cells that create red blood
cells, white blood cells and platelets and is found in the long and flat bones
yellow bone marrow and fat cells produce - ANSWER-stromal stem cells that produce
fat, cartilage and bone and are found in the long bones.
hematopoietic stem cells develop - ANSWER-prior to birth and are produced in the long
bones during childhood and childhood and then the axial skeleton in adulthood.
bone marrow microenvironment - ANSWER-the bone marrow stroma is the housing unit
and hub of cellular activity.
components of hematopiesis - ANSWER-hematopoiesis stem cells
bone marrow microenvironment
cellular adhesions molecules
chemokine, cytokines
the main objective of hematopoiesis is to - ANSWER-maintain the peripheral blood with
the proper level of blood components. the pluripotent stem cells mature and differentiate
into the myeloid progenitor cells within the bone marrow.
myeloid progenitor cells mature into - ANSWER-megakaryocytes (produce platelets)
erythrocytes
mast cells
myeloblasts
lymphoid progenitor cells mature into - ANSWER-small lymphocytes which differentiate
into bone marrow-derived cells (b cells) and thymus-derived cells (t cells)
natural killer (NK) cells
,immune function is dependent on hematopoiesis
primary organs of the immune system are involved in the production, maturation, and
immune activity.
immune function is dependent on - ANSWER-hematopoiesis
primary organs of the immune system are involved in the production, maturation, and
immune activity. - ANSWER-bone marrow
thymus gland
lymph nodes
spleen
thymus gland - ANSWER-located in the anterior mediastinum and forms t cells
lymph nodes - ANSWER-bean shape glands that cluster throughout the body in the
neck, chest, axillae, abdomen and inguinal region and function as an immunologic filter.
spleen - ANSWER-the organ responsible for filtering white cells, platelets, and other
substances.
the immune system consist of - ANSWER-innate and acquired immunity.
innate immunity occurs - ANSWER-naturally and uses phagocytes that release
inflammatory mediator and NK cells.
acquired immunity - ANSWER-is the responsible of either B cells or T cells ti antigens
b cell activation can be - ANSWER-t-cell dependent or independent
hematopoiesis can be affected by - ANSWER-by senescence
senescence - ANSWER-loss of the cells power to divide and grow
hematopoietic stem cell senescence naturally occurs - ANSWER-with age but also is
affected by cancer treatment and transplantation.
immunosenescence - ANSWER-reduction in size of thymus and function of immune
cells (not necessarily a reduction in number)
,hematopoiesis is also affected by - ANSWER-reduced size and function of thymus after
puberty
decrease cell producing marrow with age
Myeloid cells( immune function)are the - ANSWER-first responders to injury and are not
pathogen specific
lymphoid cells (immune function) respond - ANSWER-later and are pathogen specific
a human leukocyte antigen high resolution provides a type of degree of genetic math
because - ANSWER-potential for improved overall survival with a match donor and
recipient
reduce the incidence of graft versus host disease
improve engraftment rates
role of the caregiver - ANSWER-provide physical and emotional support
assist with physical recovery following HSCT
assist with take-home medication administration
perform venous care of the catheter
assess the sign of infection
monitor temperature
food preparation
provide transportation
aid in symptoms
communicate with the health care team
syngeneic - ANSWER-identical twin
a: no need to Immuno suppression
d: no graft-versus-tumor effect
matched sibiling/related - ANSWER-human leukocyte antigen(HLA) identical relative
a: no potential stem cell contamination, access to cells because the donor is related
d: only 25 % of the population has a sibling match, risk of GVHD
mismatched related - ANSWER-hla non identical
a: no potential stem cell contamination, increased numbers of potential donors
d: increase risk for gvhd, increase risk of graft failure related to hla disparity
match unrelated - ANSWER-hla identical unrelated donor
a: no potential stem cell contamination
, d: increased risk of gvhd, limited numbers of non caucasian donors, waiting period to
identify donor
mismatch unrelated - ANSWER-hla non identical unrelated donor
a: no potential stem cell contamination
d: increased risk of gvhd, high treatment related mortality
umbilical cord blood - ANSWER-umbilical cord unit
a: easy access to cell source
d: a limited number of cells, delayed time to engraftment, increase infection rates.
goals of therapy non malignant diseases - ANSWER-cell line replacement (chronic
granulomatous disease, sickle cell disease, aplastic anemia)
goal of therapy for malignant diseases - ANSWER-tumor ablation
graft versus tumor effect - ANSWER-promoted by the withdrawal of immunosuppressant
therapy
promoted by donor lymphocyte infusions
decreased in the absence of acute GVHD
associated with a higher rate of cancer relapse
immune reconstitution depends on - ANSWER-patient hematologic response to
preparative treatment
rate of engraftment
survival and longevity of mature lymphocytes present at the time of the transplant
delays on pt with chronic GVHD
quantitative recovery of immune functions does not always correlate with qualitative
recovery
immune reconstitution may take months to years
phases of immune reconstitution - ANSWER-numeric recovery of bone marrow
elements
functional recovery of cellular interactions
indications for transplantation autoimmune diseases - ANSWER-scleroderma
ms
systemic lupus erythematosus
rheumatoid arthritis
chron disease
CORRECT ANSWERS
A patient developed type 4 PTLD three years after an allogeneic HSCT. Which of the
following treatment interventions would the nurse expect an order for? -
ANSWER-Aggressive chemotherapy
Red bone marrow produces - ANSWER-hematopoietic stems cells that create red blood
cells, white blood cells and platelets and is found in the long and flat bones
yellow bone marrow and fat cells produce - ANSWER-stromal stem cells that produce
fat, cartilage and bone and are found in the long bones.
hematopoietic stem cells develop - ANSWER-prior to birth and are produced in the long
bones during childhood and childhood and then the axial skeleton in adulthood.
bone marrow microenvironment - ANSWER-the bone marrow stroma is the housing unit
and hub of cellular activity.
components of hematopiesis - ANSWER-hematopoiesis stem cells
bone marrow microenvironment
cellular adhesions molecules
chemokine, cytokines
the main objective of hematopoiesis is to - ANSWER-maintain the peripheral blood with
the proper level of blood components. the pluripotent stem cells mature and differentiate
into the myeloid progenitor cells within the bone marrow.
myeloid progenitor cells mature into - ANSWER-megakaryocytes (produce platelets)
erythrocytes
mast cells
myeloblasts
lymphoid progenitor cells mature into - ANSWER-small lymphocytes which differentiate
into bone marrow-derived cells (b cells) and thymus-derived cells (t cells)
natural killer (NK) cells
,immune function is dependent on hematopoiesis
primary organs of the immune system are involved in the production, maturation, and
immune activity.
immune function is dependent on - ANSWER-hematopoiesis
primary organs of the immune system are involved in the production, maturation, and
immune activity. - ANSWER-bone marrow
thymus gland
lymph nodes
spleen
thymus gland - ANSWER-located in the anterior mediastinum and forms t cells
lymph nodes - ANSWER-bean shape glands that cluster throughout the body in the
neck, chest, axillae, abdomen and inguinal region and function as an immunologic filter.
spleen - ANSWER-the organ responsible for filtering white cells, platelets, and other
substances.
the immune system consist of - ANSWER-innate and acquired immunity.
innate immunity occurs - ANSWER-naturally and uses phagocytes that release
inflammatory mediator and NK cells.
acquired immunity - ANSWER-is the responsible of either B cells or T cells ti antigens
b cell activation can be - ANSWER-t-cell dependent or independent
hematopoiesis can be affected by - ANSWER-by senescence
senescence - ANSWER-loss of the cells power to divide and grow
hematopoietic stem cell senescence naturally occurs - ANSWER-with age but also is
affected by cancer treatment and transplantation.
immunosenescence - ANSWER-reduction in size of thymus and function of immune
cells (not necessarily a reduction in number)
,hematopoiesis is also affected by - ANSWER-reduced size and function of thymus after
puberty
decrease cell producing marrow with age
Myeloid cells( immune function)are the - ANSWER-first responders to injury and are not
pathogen specific
lymphoid cells (immune function) respond - ANSWER-later and are pathogen specific
a human leukocyte antigen high resolution provides a type of degree of genetic math
because - ANSWER-potential for improved overall survival with a match donor and
recipient
reduce the incidence of graft versus host disease
improve engraftment rates
role of the caregiver - ANSWER-provide physical and emotional support
assist with physical recovery following HSCT
assist with take-home medication administration
perform venous care of the catheter
assess the sign of infection
monitor temperature
food preparation
provide transportation
aid in symptoms
communicate with the health care team
syngeneic - ANSWER-identical twin
a: no need to Immuno suppression
d: no graft-versus-tumor effect
matched sibiling/related - ANSWER-human leukocyte antigen(HLA) identical relative
a: no potential stem cell contamination, access to cells because the donor is related
d: only 25 % of the population has a sibling match, risk of GVHD
mismatched related - ANSWER-hla non identical
a: no potential stem cell contamination, increased numbers of potential donors
d: increase risk for gvhd, increase risk of graft failure related to hla disparity
match unrelated - ANSWER-hla identical unrelated donor
a: no potential stem cell contamination
, d: increased risk of gvhd, limited numbers of non caucasian donors, waiting period to
identify donor
mismatch unrelated - ANSWER-hla non identical unrelated donor
a: no potential stem cell contamination
d: increased risk of gvhd, high treatment related mortality
umbilical cord blood - ANSWER-umbilical cord unit
a: easy access to cell source
d: a limited number of cells, delayed time to engraftment, increase infection rates.
goals of therapy non malignant diseases - ANSWER-cell line replacement (chronic
granulomatous disease, sickle cell disease, aplastic anemia)
goal of therapy for malignant diseases - ANSWER-tumor ablation
graft versus tumor effect - ANSWER-promoted by the withdrawal of immunosuppressant
therapy
promoted by donor lymphocyte infusions
decreased in the absence of acute GVHD
associated with a higher rate of cancer relapse
immune reconstitution depends on - ANSWER-patient hematologic response to
preparative treatment
rate of engraftment
survival and longevity of mature lymphocytes present at the time of the transplant
delays on pt with chronic GVHD
quantitative recovery of immune functions does not always correlate with qualitative
recovery
immune reconstitution may take months to years
phases of immune reconstitution - ANSWER-numeric recovery of bone marrow
elements
functional recovery of cellular interactions
indications for transplantation autoimmune diseases - ANSWER-scleroderma
ms
systemic lupus erythematosus
rheumatoid arthritis
chron disease
