PC707 Module 7 –Exam with 100% Verified and Updated Solutions

PC707 Module 7 –Exam with 100% Verified and Updated Solutions SSRI drug examples - answerparoxetine (Paxil) citalopram (Celexa) fluoxetine (Prozac) sertraline (Zoloft) SSRI MOA - answerSSRIs block the reuptake of serotonin, resulting in an increased concentration of serotonin in the synapse and increased activation of postsynaptic serotonin receptors. SSRI indications - answerDepression Anxiety GAD SAD, PTSD, PD, OCD SSRI Safety and Considerations - answerAbrupt discontinuation may result in withdrawal symptoms. Serotonin syndrome is a rare but serious complication. Increased suicidal ideation the first 2-3 weeks. May cause n/v, insomnia, weight gain, and sexual dysfunction. Risk for serotonin syndrome. Use caution with elderly. Start low and go slow. SSRI BBW - answerSuicide risk, especially early on, may increase. Antidepressant-induced suicide applies mainly to children, adolescents, and adults younger than 25. SSRI pregnancy and lactation - answerZoloft, Paxil, and Fluvox are safe and first-line in breastfeeding. Prozac is not the first line for breastfeeding. Avoid Paxil in pregnancy. Prozac is the most studied for children. SNRI drug examples - answervenlafaxine (Effexor) desvenlafaxine SR (Pristiq) duloxetine (Cymbalta) SNRI for anxiety - answervenlafaxine (Effexor) duloxetine (Cymbalta) SNRI indications - answerDepression Anxiety SNRI MOA - answerBoost serotonin and norepinephrine SNRI safety and considerations - answerVenlafaxine may cause HTN and must be avoided with MAOI. SNRI BBW - answerSuicide risk, especially early on, may increase. Antidepressant-induced suicide applies mainly to children, adolescents, and adults younger than 25. SNRI special consideration - answerVenlafaxine can be used for post-menopausal hot flashes TCA drug examples - answerAmitriptyline Clomipramine Doxepin Imipramine TCA indication - answerDepression TCA MOA - answerBlock reuptake of norepinephrine and serotonin. TCA safety and considerations - answerAnticholinergic side effects. Use with caution in elderly. It is contraindicated in patients with cardiac issues. Risk of cardiac toxicity. It may lead to dysrhythmias and may be fatal with overdose. D2D interactions - MAOI, CNS depressants, sympathomimetics, anticholinergic drugs. TCA BBW - answerSuicide risk, especially early on, may increase. Antidepressant-induced suicide applies mainly to children, adolescents, and adults younger than 25. TCA special considerations - answerCan be helpful for those with sleep issues. MAOI drug examples - answerIsocarboxazid Phenelzine MAOI MOA - answerIncreases the amount of norepinephrine and serotonin for release by inhibiting intraneuronal MAO-A. MAOI Safety and considerations - answerRisk for hypertensive crisis. Avoid fermented or aged f