REGIS NU641 ADV CLINICAL PHARMACOLOGY MIDTERM EXAM QUESTIONS WITH CORRECT ANSWERS 2023

hyperlipidemia - high cholesterol levels in the blood, which can lead to heart dz, stroke and other problems caused by block arteries Atherosclerosis - Changes in the walls of large arteries consisting of lipid deposits on the artery walls, which incidences can be reduced with proper treatment of hyperlipidemia Treatment goal of hyperlipidemia - lowering of the cholesterol to appropriate levels to decrease the risk of heart attack and stroke Non-pharmacology treatment - Therapeutic Lifestyle Changes (TLC) important part of treatment and are not futile Pharmacology - Medications Statins - lower cholesterol in the blood and reduce its production in the liver by blocking the enzyme that produces it; has adverse effects that can occur more frequently at higher doses. LDL cholesterol - goal of < 70 in high risk patients goal of < 100 in mod high-risk patients DM pts w/ acute coronary artery syndrome & multiple or uncontrolled risk factors; Tx = - TLC, changes in diet restrict refined carbs (sugar & liquid calories), wgt loss (pt will not be able to participate in aerobic activity if had previous MI), decreased insulin resistance, decreased BP, improved cardiovascular conditioning, limit/ restrict ETOH consumption. Which patients are easier to manage? - Patients at low risk for developing heart dz. What med is recommended if the LDL cannot be decreased by a high dose of potent statin? - Nicotinic acid Med combination to lower triglycerides and increase the HDL - a fibrate/nicotinic acid with statin Patient Education for Statin - Pt t