USMLE questions and answers

What are the two major microtubular motor proteins? Which does anterograde axonal transport, which does retrograde axonal transport? - Kinesin, Dynein Kinesin: Anterograde Dynein: Retrograde` What do you think, immunologically speaking, when you see someone with recurrent Neisseria infections? - Inability to form the membrane attack (MAC) complex this is a common complement deficiency What is the defect in Chronic Granulomatous disease? What is the pathophysiology? - NADPH Oxidase deficiency leads to the inability to kill intracellular organisms Characteristic triad of ataxia telangiectasia? - cerebellar ataxia, telangiectasias, increased risk of sinopulmonary infections What is the major immune deficiency of ataxia telangiectasia? - IgA deficiency, which predisposes to infections of the upper and lower airways (and other mucous membranes) There's a useful mnemonic for Ataxia Telangiectasia and the gene that's mutated. What is it? - ATM