USMLE STEP 1 Pharmacology Test Bank with complete solutions

USMLE STEP 1 Pharmacology Test Bank with complete solutions What are the major functions of the α1 receptor? - answerIncrease vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction What are the major functions of the α2 receptor? - answerDecrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production What are the major functions of the β1 receptor? - answerIncrease heart rate, increase contractility, increase renin release, increase lipolysis What are the major functions of the β2 receptor? - answerVasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production What are the major functions of the M1 receptor? - answerCNS, enteric nervous system What are the major functions of the M2 receptor? - answerDecrease heart rate and contractility of atria What are the major functions of the M3 receptor? - answerIncrease exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation) What are the major functions of the D1 receptor? - answerRelaxes renal vascular smooth muscle What are the major functions of the D2 receptor? - answerModulates transmitter release, especially in the brain What are the major functions of the H1 receptor? - answerIncrease nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis, pain What are the major functions of the H2 receptor? - answerIncrease gastric acid secretion What are the major functions of the V1 receptor? - answerIncrease vascular smooth muscle contraction What are the major functions of the V2 receptor? - answerIncrease H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys) What receptors are associate with Gq? - answerH1, α1, V1, M1, and M3 What receptors are associated with Gs? - answerH2, B1, B2, V2, D1 What receptors are associated with Gi? - answerM2, α2, D2 Bethanechol - answer-Direct cholinergic agonist -Activates bowel and bladder smooth muscle -Used in postoperative and neurogenic ileus -Resistant to AChE Carbachol - answer-Direct cholinergic agonist -Carbon copy of acetylcholine -Constricts pupils and relieves intraocular pressure in glaucoma Methacholine - answer-Direct cholinergic agonist -Stimulates muscarinic receptors in airways when inhaled -Used as a challenge test for diagnosis of asthma Pilocarpine - answer-Direct cholinergic agonist -Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary sphincter (closed angle glauc