PC707 Mod 1 Questions and Answers 100% Accurate(GRADED A+)

Phase 1 - ANSWER-Evaluate safety, 40-50 healthy volunteers Phase 2 - ANSWER-Evaluate efficacy, 10-100 patients Phase 3 - ANSWER-Statistical analysis of safety & efficacy, double blinded RCT Phase 4 - ANSWER-post marketing surveillance Absorption - ANSWER-The movement of a drug from the site of administration into circulation Bioavailability - ANSWER-Amount of ACTIVE drug that reaches systemic circulation Distribution - ANSWER-The movement of a drug form systemic circulation to the site of action Protein binding - ANSWER-Drugs are inactive when bound, free circulating drug is available for use Agonist - ANSWER-Drug that activates it's receptor Antagonist - ANSWER-Deactivates receptor/ prevents receptor activation Metabolism - ANSWER-Enzymatic alteration of a drug Induction - ANSWER-Drugs which increase rate of metabolism Decreases AUC Drug may not reach therapeutic level Inhibitors - ANSWER-Drugs that decrease the rate of metabolism Increased AUC Drug may become toxic/ more severe adverse effects Prodrug - ANSWER-Drug which is inactive until it is metabolized Able to cross BBB prior to activation Hepatic first pass effect - ANSWER-Rapid inactivation of drug when given PO Drug may not reach therapeutic level Consider parenteral administration Half life - ANSWER-Time required for drug to decrease by 50% in circulation