BMTCN Medication questions n answers graded A+

BMTCN MedicationATG - correct answer Immune Suppressant. not recommended for reduced intensity regimens s/s pulm edema, hepatic dysfunction. Skin rash,joint pains(serum Sickness-TREATED WITH STEROIDS) Used before Allo for immunosuppression and later to treat GVHD. BCNU(carmustine) - correct answer nephro toxic pulm toxic-cough, dyspnea, Busulfan - correct answer neurotoxic SEIZURE-use levetiracetam hepatitis, VOD, rash, hairloss may be permanent pulmonary fibrosis premenopausal ovarian suppression Cyclophosphamide - correct answer MESNA and hydration can be used to prevent HEMORRAGIC CYSTITIS. CARDIO TOXIC- SIADH-hyponatremia and seizures.-free water restriction(furosimide) pulmonary toxic. Etoposide - correct answer anaphylaxis GI toxic plantr and palmar burning CARDIO TOXIC PERIPHERAL NEUROPATHY Fludarabine - correct answer generally well tolerated Melphalan - correct answer pulmonary toxic. mucositis TBI - correct answer fatigue swelling of saliva glands sterility acute pneumonitis(diffuse alveolar hemorrage) CATARACTS RENAL DYSFUNCTION Carboplatin - correct answer ototoxic peripheral neuropathy cytarabine - correct answer capillary leak syndrome Trimethoprim (TMP) Sulfamethoxazole (SMX) - correct answer prophylactic used to treat PCP bacteria 6 months or longer acyclovir - correct answer antiviral used to prevent HSV ganciclovir - correct answer antiviral used to prevent CMV Fluconazole - correct answer anti-fungal used to treat Candida voriconazole and posconazole - correct answer antifungals used to prevent aspergillus CNI(cyclosporin and tacrolimus) - correct answer used to prevent GVHD