BMTCN Test B correctly answered rated A+

BMTCN Test B Transplant-related toxicity is a barrier that contributes to the underutilization for which of the following diseases? A. Non-Hodgkin lymphoma B. Acute myeloid leukemia C. Sickle cell disease D. Neuroblastoma - correct answer C. Sickle cell disease Despite success of HSCT in sickle cell disease, barriers to successful HSCT include lack of a suitable donor, transplant related toxicity and immunologic graft rejection. Which of the following is a chemokine receptor that helps to regulate stem cell release into the peripheral circulation? A. CXCR4 B. CD34 C. CD14 D. CCR7 - correct answer A. CXCR4 CXCR4 has been identified as being important in the regulation of trafficking and homing of cells involved in hematopoiesis and the immune system. Which of the following is a disadvantage of a syngeneic transplant? A. Prolonged immunosuppression is required B. Limited supply of stem cells C. Longer time to engraftment D. Lack of graft-versus-tumor effect - correct answer D. Lack of graft-versus-tumor effect A syngeneic transplant lacks the graft-versus-tumor effect which is beneficial for the patient. What is an advantage of using umbilical cord blood for an HSCT? A. An HLA match with the recipient is not required. B. An unlimited supply of stem cells is available. C. The graft-versus tumor effect is avoided. D. The cells exhibit an earlier time to engraftment. - correct answer A. An HLA match with the recipient is not required. A true HLA match is not required when using umbilical cord blood because the cells have not yet matured. Which of the following is an advantage of using bone marrow as a source of stem cells? A. Cells engraft more quickly B. Takes less time to collect cells C. Cells are more mature D. Less risk of infection - correct answer B. Takes less time to collect cells Obtaining cells from the bone marrow is a much faster process than obtaining them from the peripheral blood. It is important to teach patients early in the transplant process to avoid contact with fresh plants to prevent infection with: A. cytomegalovirus. B. Pneumocystis jiroveci.