BMTCN Review Chapter 2-Types of Transplants and Sources of Stem Cells fully solved graded A+ 2023/2024

BMTCN Review Chapter 2-Types of Transplants and Sources of Stem CellsTypes of SCT (3) - correct answer -Allogeneic -Syngeneic -Autologous Stem Cell Sources (3) - correct answer -Peripheral Blood (PBSCT) -Bone Marrow -Umbilical Cord (UCB) Specific Types of Allogeneic Transplant (6) - correct answer -Syngeneic -Matched sibling/related -Mismatch related -Matched unrelated -Mismatched unrelated -Umbilical cord Syngeneic (source, advantages, disadvantages) - correct answer -Identical twin -No need for immunosuppression, disease free source -No graft vs tumor effect Allogeneic (source, advantages, disadvantages) - correct answer -HLA matching, non self -Disease free stem cell source, Potential for graft versus tumor effect -Graft-versus-host-disease (GVHD), Substantial morbidity and mortality, Donor procurement, Immunosuppressive medication Autologous (source, advantages, disadvantages) - correct answer -self -Easily available source of stem cells, No risk of graft-versus-host-disease (GVHD), Decreased morbidity and mortality, Less costly, Early engraftment -Possible contamination of undetectable stem cells, No opportunity for graft vs. tumor effect. Graft vs Tumor Effect - correct answer -Occurs after allogeneic HST -Immune response to recipient tumor cells by immune cells present in stem cell infusion -May eliminate residual malignant cells prolonging remission Peripheral Blood - Advantages - correct answer -Typically faster engraftment: Shorter hospitalization stay -Can be done outpatient -Collection is well tolerated: No anesthesia is required -PBSC's are more mature -Increased immunologic function: Increased immunologic function compared to bone marrow/UCB Peripheral Blood - Disadvantages - correct answer -May require a central line -Collection may take several days -Side effects with apheresis -Increased risk of chronic GVHD in the allo setting Bone Marrow - Advantages - correct answer -Harvest completed in a few hours -Generally well tolerated -Decreased risk of GVHD in allo setting -Cells have more tolerant immune system due to immaturity therefore greater HLA mismatch is acceptable Bone Marrow - Disadvantages - correct answer -Requires general or epidural anesthesia