BMTCN question well answered rated A+ 2023/2024

BMTCNExample of a myeloid cell - correct answer Monocyte Hematopoiesis occurs in which area? - correct answer bone marrow which which is true about innate immunity? - correct answer it's a natural process that uses phagocytes that release inflammatory mediators in response to infection or illness aquired immunity - correct answer the response of either B cells or T cells to antigens human leukocyte antigen - correct answer -proteins that reside on the surface of cells -self v. nonself which is not an indication for an allo transplant? Breast cancer, AML, CML, MDS. - correct answer breast cancer graft v. tumor effect is promoted by which of the following? 1. withdrawal of immunosuppressants 2. a DLI 3. 1 and 2 4. more immunosuppressants - correct answer withdrawal of immunosuppressants and DLI autologous transplant - correct answer -removing stem cells from the patient with the intent to reinfuse at a later date -have to be disease free -cells are cryopreserved advantages of an auto transplant - correct answer -cells are available -less side effects -early engraftment -low risk of GVH matched related donor - correct answer most often a sibling haploidentical - correct answer half-matched related advantages of an allogeneic transplant - correct answer -disease free cells -potential for graft v. tumor disadvantages of an allo transplant - correct answer -more side effects -immunosuppresion therapy -GVHD advantages of peripheral blood stem cells (PBSC) - correct answer -engraftment faster -outpatient setting -no anesthesia necessary for donor disadvantages of PBSC - correct answer -donor may need a central line -collection could take days to get enough cells -Apheresis has side effects like electrolyte imbalances and thrombocytopenia -chronic GVHD more likely Advantages of bone marrow stem cells - correct answer -quicker harvest of cells -decreased GVHD disadvantages of bone marrow stem cell collection - correct answer -general anesthesia -longer time to engraft