ONS Chemotherapy Immunotherapy Certificate Exam (2023/ 2024 Update) Questions and Verified Answers|100% Correct- Grade A

ONS Chemotherapy Immunotherapy Certificate Exam (2023/ 2024 Update) Questions and Verified Answers|100% Correct- Grade A Q: How is relative dose intensity (RDI) calculated? Answer: By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen Q: How do alkylating agents work? Answer: By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death Q: 3 subcategories of alkylating agents: Answer: 1. Nitrogen mustards 2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work similarly) 3. Nitrosoureas Q: Most common subcategory of alkylating agents: Answer: Nitrogen mustards Q: Common alkylating agents: Answer: Cyclophosphamide (Cytoxan) Ifosfamide (Ifex) Bendamustine (Treanda) Q: Common platinum-based agents: Answer: Cisplatin (Platinol) Carboplatin (Paraplatin) Q: What is unique about nitrosoureas agents? Answer: Able to cross the blood-brain barrier; can be effective in treating some brain tumors Q: Common nitrosoureas agents: Answer: Carmustine (BiCNU) Lomustine (CeeNu) Streptozocin (Zanosar) Q: Hypersensitivity can occur with late doses of: Answer: Carboplatin Q: These agents are typically categorized as highly emetogenic: Answer: 1. Alkylating agents 2. Nitrosoureas Q: Pre-administration labs for alkylating agents and nitrosoureas: Answer: BUN Creatinine CBC w/ diff Q: What is the medication Mesna used for? Answer: Bladder protectant with administration of cyclophosphamide or ifosfamide Q: Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days following treatment Answer: Oxaliplatin Q: How do antimetabolites function? Answer: By blocking DNA and RNA growth by interfering with enzymes needed for normal cell metabolism Q: Antimetabolites work in the ___ phase. Answer: S Q: What types of cells are best affected by antimetabolites? Answer: Cells with high division rates Q: Common side effects of antimetabolites: Answer: Myelosuppression GI toxicities Photosensitivity Hand-foot syndrome Q: Common antimetabolite drugs: Answer: Azacitidine Capecitabine 5-FU Cytarabine Decitabine Methotrexate Q: The institute for Safe Medication Practices recommends what route of administration for vincristine?