MERU UNIVERSITY OF SCIENCE AND TECHNOLOGY
P.O. Box 972-60200 – Meru-Kenya.
Tel: +254 (0)799529958, +254 (0)799529959, +254 (0)712524293
Website: www.must.ac.ke Email:
UNIVERSITY EXAMINATIONS 2021/2022
FIRST YEAR SECOND SEMESTER EXAMINATION FOR THE DEGREE BACHELOR OF
SCIENCE IN CLINICAL MEDICINE AND COMMUNITY HEALTH
CCM 3123: MEDICAL BIOCHEMISTRY II
DATE: MAY 2022 TIME: 3 HOURS
INSTRUCTIONS:
1. The exam consists of Three sections
2. Section one Short answer Questions
3. Section two long answer Questions
4. Section three multiple choice questions
5. All questions are compulsory
SECTION ONE: MULTIPLE CHOICE QUESTIONS (MCQS) (20 MARKS)
1. Amino acids are an important substrate for gluconeogenesis during fasting. The following
are the major gluconeogenic amino acid received by the liver
a. Alanine
b. Glycine
c. Cysteine
d. Leucine
e. Valine
2. A 19 year old patient with type 1 diabetes was admitted to hospital with blood glucose
level of 400gm/dl(reference range 80-100mg/dl). One hour after an insulin infusion was
begun, her blood glucose level decreased to 320 mg/dl. One hour later, it was 230mg/dl.
The blood glucose level decreased because insulin
Meru University of Science & Technology is ISO 9001:2015 Certified
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, a. Inhibits muscle glycogenolysis
b. Stimulates glycogenolysis in liver
c. Stimulates lipogenesis
d. Inhibits synthesis of ketone bodies from blood glucose
e. Stimulates the conversion of glucose to glycogen and trigycerides in the liver
3. The following statements are true about bilirubin
a. It is formed in the spleen
b. Bilirubin is bound to albumin in plasma
c. It is hydrophilic
d. Bilirubin is bound to globulin in plasma
e. Bilirubin is conjugated in the spleen
4. A 10-year old patient is diagnosed with cori disease. The following are the characteristics
of the disease
a. Deficiency in the branching enzyme
b. It is the most common of the glycogen storage diseases
c. Enlarge liver
d. Enlarged muscles
e. Deficiency in debranching enzyme
5. The following statement is true about lipid transport
a. LDL are smaller and denser than HDL
b. Triglycerides are synthesized in the intestinal mucosa
c. Apolipoproteins form part of the lipoproteins
d. Lipids are exported out of the liver by LDL
e. LDL enters cells by endocytosis
6. During lipogenesis
a. Malonyl CoA is formed from UDP glucose
b. NADPH produces reducing equivalents
c. Triglycerides are stored in the liver
d. Acetyl CoA synthase is involved
e. The muscles are involved
7. The urea cycle is important in detoxification of ammonia. The cycle is catalyzed by the
following enzymes
Meru University of Science & Technology is ISO 9001:2015 Certified
Foundation of Innovations Page 2
P.O. Box 972-60200 – Meru-Kenya.
Tel: +254 (0)799529958, +254 (0)799529959, +254 (0)712524293
Website: www.must.ac.ke Email:
UNIVERSITY EXAMINATIONS 2021/2022
FIRST YEAR SECOND SEMESTER EXAMINATION FOR THE DEGREE BACHELOR OF
SCIENCE IN CLINICAL MEDICINE AND COMMUNITY HEALTH
CCM 3123: MEDICAL BIOCHEMISTRY II
DATE: MAY 2022 TIME: 3 HOURS
INSTRUCTIONS:
1. The exam consists of Three sections
2. Section one Short answer Questions
3. Section two long answer Questions
4. Section three multiple choice questions
5. All questions are compulsory
SECTION ONE: MULTIPLE CHOICE QUESTIONS (MCQS) (20 MARKS)
1. Amino acids are an important substrate for gluconeogenesis during fasting. The following
are the major gluconeogenic amino acid received by the liver
a. Alanine
b. Glycine
c. Cysteine
d. Leucine
e. Valine
2. A 19 year old patient with type 1 diabetes was admitted to hospital with blood glucose
level of 400gm/dl(reference range 80-100mg/dl). One hour after an insulin infusion was
begun, her blood glucose level decreased to 320 mg/dl. One hour later, it was 230mg/dl.
The blood glucose level decreased because insulin
Meru University of Science & Technology is ISO 9001:2015 Certified
Foundation of Innovations Page 1
, a. Inhibits muscle glycogenolysis
b. Stimulates glycogenolysis in liver
c. Stimulates lipogenesis
d. Inhibits synthesis of ketone bodies from blood glucose
e. Stimulates the conversion of glucose to glycogen and trigycerides in the liver
3. The following statements are true about bilirubin
a. It is formed in the spleen
b. Bilirubin is bound to albumin in plasma
c. It is hydrophilic
d. Bilirubin is bound to globulin in plasma
e. Bilirubin is conjugated in the spleen
4. A 10-year old patient is diagnosed with cori disease. The following are the characteristics
of the disease
a. Deficiency in the branching enzyme
b. It is the most common of the glycogen storage diseases
c. Enlarge liver
d. Enlarged muscles
e. Deficiency in debranching enzyme
5. The following statement is true about lipid transport
a. LDL are smaller and denser than HDL
b. Triglycerides are synthesized in the intestinal mucosa
c. Apolipoproteins form part of the lipoproteins
d. Lipids are exported out of the liver by LDL
e. LDL enters cells by endocytosis
6. During lipogenesis
a. Malonyl CoA is formed from UDP glucose
b. NADPH produces reducing equivalents
c. Triglycerides are stored in the liver
d. Acetyl CoA synthase is involved
e. The muscles are involved
7. The urea cycle is important in detoxification of ammonia. The cycle is catalyzed by the
following enzymes
Meru University of Science & Technology is ISO 9001:2015 Certified
Foundation of Innovations Page 2
