WCU NURS 180 Pharmacology Midterm (Passed!)

Proton Pump Inhibitors correct answers -Omeprazole Indications: PUD, GERD -MOA: inhibits hydrogen potassium-ATPase enzyme system pump -AE: N/V/D, bone loss -NI: Administer before 1st meal 20-30 mins, proton pump activated by food, inc. Ca & vit D in food or supplement, weight bearing exercises -Interactions: St. John's wort & ETOH dec. drug levels -Contraindicated: Children, Preg. Category C. Histamine2-Receptor Antagonists correct answers Ranitidine (Zantac) MOA: Block H2 Receptors in stomach, decreases amount and acidity of stomach acid. AE: N/V/D/C NI: Drink Fluids, Don't give antacids within 1 hour. Precaution: COPD Mucosal Protectant correct answers Sucralfate (Carafate) MOA: Causes chemical reaction, creates gel like substance, Coats ulcers, Creates barrier between stomach & gastric secretions AE: n/d/c & Dyspepsia NI: Administer on empty stomach, QID don't give antacids w/in 30-60 mins., inc. fluid/fiber Precautions: Renal dysfunction Contraindicated: Children Interactions: interfere w/ absorption of digoxin, phenytoin, & warfarin (give 2 hrs apart) Antacids correct answers aluminum hydroxide MOA: Neutralizes Gastric Acid AE: N/V/D, hypophosphatemia, hypomagnesemia NI: I&O, phos & mag levels, inc. fluid, activity level, milk alkali syndrome: Ca antacid & milk (Red Flag) Contraindication: GI obstruction Precautions: Renal dysfunction, dehydration, dec. bowel motility Prostaglandin analogs correct answers Misoprostol (Cytotec) MOA: Acts as prostaglandin in GI tract, dec. gastric acid secretion, inc. secretion of bicarb & protective mucus AE: n/d/ABD pain, *dyspepsia, *uterine cramps (dysmenorrhea), spotting NI: administer w/ meals & at HS, assess preg. status, drink fluids, take w/ food, report menstrual changes Contraindications: Preg. risk category X, children antibiotics correct answers Metronidazole NI: Monitor for c-diff, FULL COURSE, take w/ food, combination therapy (2-3 ABXs X 14 days)