ISBB Questions fully solved graded A+ 2023

ISBB QuestionsMHC are genes located in short arm of chromosome 6 In adaptive immunity, what cell recognizes processed peptide/antigen in conjunction with HLA-I molecules? Class I MHC molecules A. peptides synthesized de novo from endogenous antigens B. peptides from soluble or particulate antigen (exogenous) C. Either D. Neither CREST Syndrome includes Esophageal dysmotility Deficiency of which of the ff complement components can lead to recurrent infections with Neisseria spp? C2, C3, C5, or (C1,C4& C2) Which of the ff mitogens can activate T lymphocytes? A. PHA B. Con A C. LPS D. PHA and Con A Rh5, accdg to the Rosenfield nomenclature is equivalent to? e Anti-H can be obtained from Ulex europaeus Changes that occur to blood during storage? A. Inc ATP lvls B. Inc Lactic acid C. Inc 2,3 DPG D. Inc pH When both the genes for secretor and H are present, Lewis becomes? Lewis a substance is converted to Lewis b substance The ff antigens belong to the Kell blood group system except: A. Kpa B. Jsa C. K D. NOTA Truth about McLeod phenotype A. RBCs of pxs with this phenotype are often acanthocytic B. It is inherited as autosomal recessive fashion C. RBC of pxs with this phenotype lacks Km but strongly expresses Kx D. AOTA Most common Rh pheontype among the black population Dce The antibody ____ is easy neutralized with fresh urine while antibody to ___ can be neutralized by hydatid cyst fluid Sda; P The main source of factor D of the alternative pathway of complement activation is ___ is destroyed when treated with enzymes while ____ is enhanced by acidifying the patient serum A. K - Anti-N B. Jk - Anti-D C. Fy - Anti-M D. Jk - Anti-M Samples required to perform major crossmatch DCPS During CIE (Countercurrent immunoelectrophoresis), the antigens move towards the _____, while the antibodies move towards the ______ What would be the absorption pattern of IM in the Davidsohn differential test? Sample for pre transfusion testing should be collected for no more than 7 days before transfusion. Pre transfusion samples should be retained for at least 7 days after transfusion Which statements are correct? Transfusion of any blood component should be finished within 3 hrs Combination of electrophoresis and single immunodiffusion is also known as If the seal of plt concentrate bag stored at 20-24 deg Celcius is broken, the plts should be transfused within how many hours Blood component used for the prevention of possible gvhd A. Irradiated components B. Leukoreduced components C. Both D. Neither Frozen RBCs are subjected to deglycerolization before transfusion. A deglycerolized rbc pack should then be transfused within _____ ABO typing of a certain patient yields the ff rxns Anti A= 4+ Anti-B= (-) Anti-A1B= 4+ Anti-A1= (-) A1 cells= 2+ B cells= 4+ The rxn may because: A. Pxs AB with anti-A1 B. Pxs A1 with acquired B C. Pxs is A2 with anti-A1 D. Pxs has increased conc. of proteins in serum Which blood group appears to facilitate the attachment the attachment of H. pylori to the gastric mucosa You are working on a spx in the laboratory that you believe to be a Bombay phenotype. Which of the ff rxns would you expect to see? The high glycerol method of freezing red cells involves the use of? A. 40% glycerol B. 20% glycerol C. Rapid Freezing technique D. A and C Anti-extractable nuclear antigens are most likely assoc with which of the ff antinuclear antibody immunofluorescent patterns? A. speckled B. Rim C. Diffuse D. Nucleolar In the anti-double stranded DNA procedure, the antigen most commonly used is? OX-19 antigen are derived from P. mirabilis. Weil Felix is a reverse passive agglutination test for the detection of antibodies to Rickettsial spp Which statements are true? Passive agglutination is a type of agglutination rxn in which ____ are affixed in the particle carrier to detect _____. An example of this is ______. 1. Ab 2. Ag 3. CRP latex agglutination test 4.ASO latex agglutination test The mechanism by which penicillin causes a positive DAT