Opioid Overdose 2023 Exam

Common drug related causes of death - ANSWER-Opoid overdose: One of the most frequent causes of drug-related death in the US, exceeding cocaine and heroin combined Risk factors for opioid overdose - ANSWER-Depression, Anxiety, Stress Addiction to other substances (nicotine/alcohol) Mental disorders like schizophrenia, bipolar, MDD, compulsive disorders (gambling) A patient's symptoms, presence of drugs at the scene, and availability of opioids can be helpful indicators of risk. DOA of IR vs ER oxycodone - ANSWER-IR: 3-6 hours ER: 8-12 hours _________ accounts for 1/3 of deaths from opioid analgesics - ANSWER-methadone Triad of symptoms - ANSWER-Respiratory depression Miosis Unconsciousness Respiratory depression is defined as - ANSWER-< 12 bpm Naloxone MOA - ANSWER-mu opioid receptor antagonist Naloxone dosing - ANSWER-Initial adult dose: 0.04 mg, pediatric dose: 0.1 mg/kg 2. In an increase in respiratory rate does not occur in 2-3 minutes, give 0.5 mg of naloxone. 3. If no response in 2-3 minutes, give 2 mg of naloxone. 4. If no response in 2-3 minutes, give 4 mg of naloxone. 5. If no response in 2-3 minutes, give 10 mg of naloxone. 6. If no response in 2-3 minutes, give 15 mg of naloxone. Goals of therapy for Naloxone - ANSWER-Increase to adequate ventilation Buprenorphine brand names: transdermal patch - ANSWER-Butrans Buprenorphine brand names: buccal film - ANSWER-belbuca Buprenorphine brand names: intradermal implant - ANSWER-Buprenex Buprenorphine brand names: sublingual tablet - ANSWER-Subutex Which formulations of Buprenorphine are indicated for severe chronic pain? - ANSWER-Butrans and Belbuca