ABGC final review (100% Errorless Answers)

Gail Model Pros correct answers Lifetime and 5-year breast cancer risk Determine eligibility to take chemoprevention Includes age, age at first live birth, age at menarche, # of FDR with BC, breast biopsy, atypical hyperplasia, race Gail model cons correct answers NOT used for women with LCIS/DCIS No other cancers Does not consider SDR Does not consider paternal history Does not consider age of onset for cancers Underestimates risk Claus Tables correct answers Calculate BC risk based on family history of breast cancer only Breast cancer prior probability models correct answers BRCAPro Penn II BOADICEA Tyler-Cuzick Myriad High penetrance breast cancer genes correct answers BRCA1: 20-30% BRCA2: 10-20% TP53 (LFS) PTEN (Cowden) PALB2 CDH1 STK11 (PJS) Triple negative breast cancer correct answers BRCA1 Most common cancer in women with LFS correct answers breast cancer Breast cancer age of onset comparison between BRCA and LFS correct answers Younger age of onset in LFS Order of risk of developing colon cancer in syndromes correct answers FAP HNPCC JPC PJS Homozygous loss of PMS2 correct answers Increased risk for colon cancer at very young age Brain tumors Other cancers Juvenile polyps type correct answers Hamartomatous