UNE BioChem 1005 Final Exam Questions
With Complete Solutions
Somatostatin reduces the secretion of both glucagon and insulin
through which of the following mechanisms?
a. Somatostatin activates an activator G-protein
b. Somatostatin activates MAPK cascade
c. Somatostatin activates an inhibitory G-protein
d. Somatostatin uses Ca+2 as a downstream signal correct
answer: c. Somatostatin activates an inhibitory G-protein
Insulin mediated glucose uptake by muscle and adipose tissue is
a result of which of the following mechanisms?
a. Translocation of GLUT 4 receptors to the cell surface
b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell
surface
c. Passive diffusion
d. Activation of protein kinase A correct answer: a.
Translocation of GLUT 4 receptors to the cell surface
The alanine - glucose cycle is primarily used for which of the
following purposes?
a. To move ammonia from skeletal muscle to the liver
b. To generate ATP for the skeletal muscle
c. To move glucose from the skeletal muscle to the liver
,d. To move alanine from the liver to the skeletal muscle correct
answer: a. To move ammonia from skeletal muscle to the liver
Which statement best illustrates an example of post translational
gene regulation?
a. Protein kinase A mediated phosphorylation of glycogen
phosphorylase
b. Cortisol binds a cytosolic receptor, translocates to the nucleus
and binds a GRE
c. Iron binding the iron response elements binding protein
(IRE_BP) allowing for translation of ferritin mRNA
d. DNA histone associations leading to super-coiling of DNA
correct answer: a. Protein kinase A mediated phosphorylation of
glycogen phosphorylase
Which of the following hormones is released from the liver in
response to increased levels of growth hormone?
a. Cortisol
b. Thyroid hormone
c. Somatostatin
d. Insulin-like growth factor (IGF) correct answer: d. Insulin-
like growth factor (IGF)
Autophagy is process involves degradation of protein. Under
conditions of high energy (HIGH ATP) which of the following
is true regarding regulation of this process?
a. Akt is inactive
b. AMPK is actice and phosphorylates TSC1/TSC2 Complex
, c. mTOR is activated
d. Rheb is bound to GDP correct answer: c. mTOR is activated
Synthesis of which of the following lipoproteins would be
elevated after a carbohydrate rich meal?
a. HDL
b. Chylomicrons
c. LDL
d. VLDL correct answer: d. VLDL
The synthesis of N-acetylglutamate (NAGS) is required for the
activity of the urea cycle. This compound stimulates the activity
of which of the following enzymes?
a. Arginase
b. Carbamoyl phosphate synthetase I (CPSI)
c. Ornithine transcarbamoylase
d. Carbamoyl phosphate synthetase II (CPSII) correct answer:
b. Carbamoyl phosphate synthetase I (CPSI)
A male infant starts to show signs of lethargy rapidly after birth.
Upon evaluation he is determined to have a deficiency in n-
acetylglutamate synthesis. Based on this information, which of
the following would consistent with this diagnosis?
a. Elevated levels of arginine
b. Decreased levels of carbamoyl phosphate
c. Decreased levels of ammonia
d. Elevated levels of citrulline correct answer: b. Decreased
levels of carbamoyl phosphate
With Complete Solutions
Somatostatin reduces the secretion of both glucagon and insulin
through which of the following mechanisms?
a. Somatostatin activates an activator G-protein
b. Somatostatin activates MAPK cascade
c. Somatostatin activates an inhibitory G-protein
d. Somatostatin uses Ca+2 as a downstream signal correct
answer: c. Somatostatin activates an inhibitory G-protein
Insulin mediated glucose uptake by muscle and adipose tissue is
a result of which of the following mechanisms?
a. Translocation of GLUT 4 receptors to the cell surface
b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell
surface
c. Passive diffusion
d. Activation of protein kinase A correct answer: a.
Translocation of GLUT 4 receptors to the cell surface
The alanine - glucose cycle is primarily used for which of the
following purposes?
a. To move ammonia from skeletal muscle to the liver
b. To generate ATP for the skeletal muscle
c. To move glucose from the skeletal muscle to the liver
,d. To move alanine from the liver to the skeletal muscle correct
answer: a. To move ammonia from skeletal muscle to the liver
Which statement best illustrates an example of post translational
gene regulation?
a. Protein kinase A mediated phosphorylation of glycogen
phosphorylase
b. Cortisol binds a cytosolic receptor, translocates to the nucleus
and binds a GRE
c. Iron binding the iron response elements binding protein
(IRE_BP) allowing for translation of ferritin mRNA
d. DNA histone associations leading to super-coiling of DNA
correct answer: a. Protein kinase A mediated phosphorylation of
glycogen phosphorylase
Which of the following hormones is released from the liver in
response to increased levels of growth hormone?
a. Cortisol
b. Thyroid hormone
c. Somatostatin
d. Insulin-like growth factor (IGF) correct answer: d. Insulin-
like growth factor (IGF)
Autophagy is process involves degradation of protein. Under
conditions of high energy (HIGH ATP) which of the following
is true regarding regulation of this process?
a. Akt is inactive
b. AMPK is actice and phosphorylates TSC1/TSC2 Complex
, c. mTOR is activated
d. Rheb is bound to GDP correct answer: c. mTOR is activated
Synthesis of which of the following lipoproteins would be
elevated after a carbohydrate rich meal?
a. HDL
b. Chylomicrons
c. LDL
d. VLDL correct answer: d. VLDL
The synthesis of N-acetylglutamate (NAGS) is required for the
activity of the urea cycle. This compound stimulates the activity
of which of the following enzymes?
a. Arginase
b. Carbamoyl phosphate synthetase I (CPSI)
c. Ornithine transcarbamoylase
d. Carbamoyl phosphate synthetase II (CPSII) correct answer:
b. Carbamoyl phosphate synthetase I (CPSI)
A male infant starts to show signs of lethargy rapidly after birth.
Upon evaluation he is determined to have a deficiency in n-
acetylglutamate synthesis. Based on this information, which of
the following would consistent with this diagnosis?
a. Elevated levels of arginine
b. Decreased levels of carbamoyl phosphate
c. Decreased levels of ammonia
d. Elevated levels of citrulline correct answer: b. Decreased
levels of carbamoyl phosphate
