USMLE step 1 Pharmacology - Autonomic Nervous System Exam

USMLE step 1 Pharmacology - Autonomic Nervous System Exam α1, α2, β1, β2 - ANS-Epinephrine α1, α2, β1 (no β2 activity) - ANS-Norepinephrine Causes an inhibitory cell hyperpolarization - ANS-GABA Uses DAG & IP3 as 2nd messengers, Parasympathetic control - ANS-Muscarinic-r Cholinergic. ↑ GI & Bladder motility. Txt atonic bladder post-op - ANS-Bethanechol Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation. Txt acute glaucoma - ANS-Pilocarpine Organophosphate. Irreversible acetylcholinesterase (-)r - ANS-Isoflurophate 2PAM. Reverses organophosphate binding to acetylcholinesterase, - ANS-Pralidoxime Reversible acetylcholinesterase (-)r, Txt Myasthenia Gravis - ANS-Neostigmine Anitbodies to Ach-r. ↑g muscular weakness due to Achs weak postsynaptic effect @ NMJ. Inactivates-r - ANS-Myasthenia Gravis Nondepol. Competitive cholinergic N-r (-)r., Prevents Ach binding but does not activate NMJ, ↑ Histamine release= ↓ BP & ↑ bronchospasm - ANS-Tubocurium Nonselectively binds N-r of the PS- and SNS - ANS-Trimethaphan More potent than tubocurium w/o histamine release - ANS-Pancurium Depol. Non competitive (-)r of muscle aciton, Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion. - ANS-Succinylcholine receptor? Mydriasis due to norepinephrine. Prazosin (-). - ANS-α1 & Eye receptor? Miosis due to Ach. Atropine (-). - ANS-M-r & Eye Post ganglionic symapthetic fibers releases norepinephrine - ANS-Sympathetic CONTINUES...