Medical Biochemistry Final, UNE Biochemistry Final, UNE Biochemistry Final, Final, Final Exam Review UNE medical biochemistry (2022/2023) Rated A+

Medical Biochemistry Final, UNE Biochemistry Final, UNE Biochemistry Final, Final, Final Exam Review UNE medical biochemistry (2022/2023) Rated A+ In glycolysis, ____ is considered the committed step in the pathway. PFK-1 Phospholipids are made up of one or more fatty acids, a core, a phosphate, and which one of the following? alcohol cholesterol has a unique chemical structure with four fused rings that allows it to serve what critical role in our bodies regulating membrane fluidity Pyruvate plays a central role in intermediary metabolism. Which three chemical functional groups does it contain? carboxylic acid, methyl, ketone The urea cycle takes place in which subcellular location(s)? cytosol, mitochondria Which pathway below requires the use of NADPH? cholesterol biosynthesis Individuals with Lesch-Nyhan would be expected to build up which compound due to their enzyme deficiency? uric acid The urea cycle takes place in which of the following subcellular locations? the cytosol and the mitochondria Which of the following enzymes is regulated by N-acetylglutamate (NAGs)? CPS I Which of the following enzymes is the regulatory step in the urea cycle? Carbamoyl phosphate synthetase I (CPS I) A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and uracil were both greater than normal. A defect of which of the following enzymes is the most likely diagnosis? Ornithine transcarbamoylase Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-acetylglutamate (NAGs). Which of the following would be a consequence of this deficiency in the patient? Increased amino acids in the blood The cellular uptake of LDL increases intracellular cholesterol levels. This has which of the following impacts on de novo cholesterol synthesis? Increases degradation of HMG-CoA reductase Dietary cholesterol is primarily transported in the body by which of the following lipoproteins? Chylomicron A 47-year-old male is prescribed a statin (HMG-CoA reductase inhibitor) to manage his elevated LDL cholesterol. What is the initial mechanism of action for obtaining the desired effect in this man? Decreasing hepatic cholesterol biosynthesis A deficiency in the LDL receptor will result in an initial decrease in which of the following? Intracellular cholesterol A 45-year-old man has a mild heart attack and a history of vascular disease. He is placed on a Mediterranean diet and statin drug therapy. Which of the fo