UNE Biochem 1005 Unit 2 exam graded A+

UNE Biochem 1005 Unit 2 exam graded A+ 1. Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? The phosphorylation and inactivation of E1 subunit (pyruvate dehydrogenase complex 1. Which of the following intermediates is an allosteric activator of pyruvate kinase? a. Fructose 1.6 bisphosphate 1. Which of the following is the initial second messenger in the signaling cascade initiated by glucagon? a. cAMP 1. Hereditary fructose intolerance in caused by a deficiency in aldolase B. These individuals may present with hypoglycemia due to an accumulation of fructose 1-P in the cell and inhibition of which of the following pathways? a. Gluconeogenesis and glycogenolysis 1. Following insulin binding its receptor and autophosphorylation of the beta chain, what is the initial step in the cascade of events? a. Recruitment of the insulin receptor substrate 1. What sequence of enzymes allows for the synthesis of glycogen from glucose 6-P? Phosphoglucomutase, UDP-glucose phosphorylase, glycogen synthase amylo-(1,4a1,6)-transglycosylase 1. Complex II, succinate dehydrogenase, is not considered to be part of the process of oxidative phosphorylation because it is unable to do which of the following activities? a. Pump protons from the mitochondrial matrix to the intermembrane space 1. Which of the following is the primary GLUT transporter in skeletal muscle and adipose tissue? GLUT 4 1. Which of the following best describes the net effect of the 8 steps of the TCA cycle? a. This process completely oxidizes an acetyl group to carbon dioxide 1. Which of the following enzymes is correctly paired with this activator? a. Pyruvate dehydrogenase complex, pyruvate 1. ATP is a high energy molecule that is often hydrolyzed during reactions. The energy within ATP is stored primarily in which of the following compounds of the molecule? a. In the high energy phosphate bonds 1. Which of the following is a key inhibitor of the a-ketoglutarate dehydrogenase? NADH 1. As electrons flow through complexes in the inner mitochondrial membrane, protons are pumped from the matrix to the intermembrane space. Which of the following statements is most reflective of the pH in the intermembrane space? a. The pH is higher in the matrix when compared to the intermembrane space 1. Pyruvate dehydrogenase complex is highly regulated. The enzyme will be most active when which of the following compounds is high? Pyruvate