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  • Artesis Plantijn Hogeschool Antwerpen (Artesis)
  • Biomedische Laborartorium Technologie
  • Galenica
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Samenvatting - galenica: suspensies

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2022/2023 Written for academic year
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Artesis Plantijn Hogeschool Antwerpen (Artesis)
Course
Galenica
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deze samenvatting bevat alle info over het deel suspensies uit het vak galenica. het bevat afbeeldingen en notities uit de hoorcolleges.

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SUSPENSIES
DEFINITIES




EIGENSCHAPPEN/EISEN

Toepassing/Voordelen?

• Smaak farmaca maskeren
• Stabiliteit verbeteren
• Onoplosbare farmaca verwerken
• Als verlengde werking beoogd wordt

Eisen gesteld aan een goed geformuleerde suspensie?

• Goede stabiliteit (zie volgende dia)
o Sedimentatie moet vertraagd worden  zie wet van stokes
o Deeltjesgrootte gesuspendeerde stof: < 180 μm en uniform
o Viscositeit : verhogen
o Densiteitsverschil (ρv –ρvl ) zo klein mogelijk
• Goede opschudbaarheid
o Deeltjes die toch bezinken vormen makkelijk opschudbaar sediment ( caking moet
vermeden worden)
o Sediment moet zo groot mogelijk volume innemen
o Na opschudden : suspensie voldoende lang homogeen voor nauwkeurige dosering
van actief bestanddeel.

SEDIMENTATIESNELHEID

, Suspensie = Thermodynamisch LABIEL systeem - Fijn poeder, groot totaal oppervlak  Grote vrije
energie Gevolgen - verkleinen van het oppervlak - agglomeratie, floculatie - cacking, onopschudbaar
sediment

VLOKKING

Niet gevlokte suspensie  deflocculatie




Gevlokte suspensie  flocculatie




Vlokking verkregen door toevoegen van

• Electrolyten
• Surfactantia
• Polymeren

SAMENSTELLING

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biomedische laborartorium technologie
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June 23, 2023
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  • galenica
  • suspensies

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