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  • Artesis Plantijn Hogeschool Antwerpen (Artesis)
  • Biomedische Laborartorium Technologie
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Samenvatting - galenica: suspensies

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deze samenvatting bevat alle info over het deel suspensies uit het vak galenica. het bevat afbeeldingen en notities uit de hoorcolleges.

Institution
Artesis Plantijn Hogeschool Antwerpen (Artesis)
Course
Galenica









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Written for

Institution
Artesis Plantijn Hogeschool Antwerpen (Artesis)
Study
biomedische laborartorium technologie
Course
Galenica
All documents for this subject (10)

Document information

Uploaded on
June 23, 2023
Number of pages
5
Written in
2022/2023
Type
Summary

Subjects

  • galenica
  • suspensies

Content preview

SUSPENSIES
DEFINITIES




EIGENSCHAPPEN/EISEN

Toepassing/Voordelen?

• Smaak farmaca maskeren
• Stabiliteit verbeteren
• Onoplosbare farmaca verwerken
• Als verlengde werking beoogd wordt

Eisen gesteld aan een goed geformuleerde suspensie?

• Goede stabiliteit (zie volgende dia)
o Sedimentatie moet vertraagd worden  zie wet van stokes
o Deeltjesgrootte gesuspendeerde stof: < 180 μm en uniform
o Viscositeit : verhogen
o Densiteitsverschil (ρv –ρvl ) zo klein mogelijk
• Goede opschudbaarheid
o Deeltjes die toch bezinken vormen makkelijk opschudbaar sediment ( caking moet
vermeden worden)
o Sediment moet zo groot mogelijk volume innemen
o Na opschudden : suspensie voldoende lang homogeen voor nauwkeurige dosering
van actief bestanddeel.

SEDIMENTATIESNELHEID

, Suspensie = Thermodynamisch LABIEL systeem - Fijn poeder, groot totaal oppervlak  Grote vrije
energie Gevolgen - verkleinen van het oppervlak - agglomeratie, floculatie - cacking, onopschudbaar
sediment

VLOKKING

Niet gevlokte suspensie  deflocculatie




Gevlokte suspensie  flocculatie




Vlokking verkregen door toevoegen van

• Electrolyten
• Surfactantia
• Polymeren

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