HTL Fixatives questions with correct answers

Most coagulant fixatives achieve their full effect on tissue at any particular depth as soon as... - Answer they have penetrated to that depth at a concentration sufficient to cause coagulation. Fixative - Answer alters tissue by stabilizing the protein so that it is resistant to further changes. A fixative must change... - Answer the soluble contents of the cell into insoluble substances so that those substances are not lost during the subsequent processing steps. Denaturation - Answer causes the protein molecule to unfold and the internal bonds to become disrupted. In additive fixation, denaturation... - Answer enables the protein to combine chemically with a fixative molecule and the protein becomes insoluble. With nonadditive fixatives... - Answer denaturation causes the protein to become less capable of maintaining an intimate relationship with water and to become more reactive, but the fixative molecule does not combine with the protein. Funtions of Fixatives - Answer - to kill the tissue by denaturing proteins so postmortem activities of decay, putrefaction (bacterial decay), and autolysis (enzyme attack) are prevented. - to help maintain the proper relationship between cells and extracellular substances, such as the connective tissue fibers (collagen, reticulin, and elastin) and amorphous ground substance. This prevents tissue distortion.