biochem midterm, unit 2| 232 Questions| With Complete Solutions

Which of the following pathways provides the primary oxidizable fuel for skeletal muscle in the fasted state? correct answer: Lipolysis from adipose tissue In the fasted state the skeletal muscle is predominantly oxidizing free fatty acids. These are provided through the process of lipolysis in the adipose tissue. Triacylglycerols stored in the adipose are hydrolyzed to free fatty acids and transported bound to albumin in the blood stream. In the fasted state, both the liver and the skeletal muscle will use these as a primary fuel source. A suspected mutation in the cortisol receptor is discovered. Cortisol can still bind its receptor but the dimerized complex remains in the cytosol. Based on this description which region on the receptor is likely impacted? correct answer: Nuclear localization signal The glucocorticoid receptor is present in the cytosol bound to HSP90 in the absence of ligand. When cortisol binds, this dissociates the HSP90 and exposes the nuclear localization signal which is required to move the complex into the nucleus. If the complex is retained in the cytosol, this would suggest a defect in the nuclear localization signal A young woman goes to work without eating breakfast and skips lunch. In this scenario, which of the